DegronMD

Uniprot ID: Q8IZQ8

Source protein: Myocardin

Source gene: MYOCD

Class: DEG_SPOP_SBC_1

Location: 334:338

E3 ligase: SPOP

DEGRON score: 0.9909

ASA_SCORE: 98.58

COIL: 0.97

CONS_SCORE: 0.4504

DSS_SCORE: 0.7443

HELIX: 0.0192

FCONS_SCORE: 1.2171

RIG_SCORE: 0.5824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T344A	TCGA-CG-5721	STAD	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1667
p.T344A	DO38192	STAD	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.P345L	TCGA-CN-5360	HNSC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1389
p.P345L	TCGA-D3-A8GB	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1389
p.P345L	DO14662	HNSC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1389
p.P345L	DO50280	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1389
p.E328K	TCGA-EE-A29D	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1667
p.E328K	DO218440	BTCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.E328K	DO38123	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.P348L	TCGA-EE-A2GS	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.0556
p.P348L	DO37465	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.0556
p.T339M	TCGA-EY-A4KR	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.3056
p.T339M	DO48179	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.3056
p.P334S	TCGA-FI-A2D5	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.6752
p.P334S	DO41331	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.6752
p.E325K	TCGA-GF-A6C9	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.0833
p.E325K	DO51254	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.0833
p.N327H	TCGA-QS-A5YQ	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1389
p.N327H	DO49073	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1389
p.S342N	DO231998	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.L346F	DO229038	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1111
p.P348S	DO220875	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.0556
p.S347P	SIDM00878	Breast Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.0833
p.S347P	ACH-000930	Breast Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.0833
p.S347P	HCC1569	breast	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15117	FYN-binding protein 1	DEG_SPOP_SBC_1	26:30	PNSSS	SPOP	0.994	More...
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SPOP_SBC_1	7:11	PNSSS	SPOP	0.7976	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2093:2097	PNSSS	SPOP	0.9431	More...
O94812	BAI1-associated protein 3	DEG_SPOP_SBC_1	423:427	PNSSS	SPOP	0.6757	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1389:1393	PNSSS	SPOP	0.9056	More...
P56177	Homeobox protein DLX-1	DEG_SPOP_SBC_1	218:222	PNSSS	SPOP	0.9889	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	177:181	PNSSS	SPOP	0.9508	More...
Q16832	Discoidin domain-containing receptor 2	DEG_SPOP_SBC_1	672:676	PNSSS	SPOP	0.678	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	606:610	PNSSS	SPOP	0.9659	More...
Q7L7V1	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32	DEG_SPOP_SBC_1	9:13	PNSSS	SPOP	0.6156	More...
Q86V97	Kelch repeat and BTB domain-containing protein 6	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.8742	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	334:338	PNSSS	SPOP	0.9909	More...
Q8N9N5	Protein BANP	DEG_SPOP_SBC_1	338:342	PNSSS	SPOP	0.9929	More...
Q8NHG8	E3 ubiquitin-protein ligase ZNRF2	DEG_SPOP_SBC_1	104:108	PNSSS	SPOP	0.9921	More...
Q8WVZ9	Kelch repeat and BTB domain-containing protein 7	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.9389	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	1008:1012	PNSSS	SPOP	0.7835	More...
Q96N67	Dedicator of cytokinesis protein 7	DEG_SPOP_SBC_1	860:864	PNSSS	SPOP	0.9622	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	216:220	PNSSS	SPOP	0.9952	More...
Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	DEG_SPOP_SBC_1	298:302	PNSSS	SPOP	0.9384	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1056:1060	PNSSS	SPOP	0.9777	More...
Q15434	RNA-binding motif, single-stranded-interacting protein 2	DEG_SPOP_SBC_1	41:45	PNSSS	SPOP	0.6568	More...
Q9BXY5	Calcyphosin-2	DEG_SPOP_SBC_1	92:96	PNSSS	SPOP	0.9192	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNSSS

Degron related mutations and impact score

Drug responses associated with MYOCD mutations

All proteins holding degron of PNSSS