DegronMD - O94812(BAIAP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L414Q	TCGA-44-3396	LUAD	TCGA	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.0833
p.L414Q	DO23559	LUAD	ICGC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.0833
p.R415L	TCGA-44-3396	LUAD	TCGA	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1111
p.R415L	DO23559	LUAD	ICGC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1111
p.G98W	TCGA-62-8399	LUAD	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2778
p.G98W	TCGA-F7-A620	HNSC	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2778
p.G98W	DO44445	HNSC	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2778
p.G98W	DO24606	LUAD	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2778
p.E99K	TCGA-91-6836	LUAD	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.E99K	DO23854	LUAD	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.R112H	TCGA-AX-A2HD	UCEC	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2222
p.R112H	DO42608	UCEC	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2222
p.E108Q	TCGA-BB-4227	HNSC	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.5633
p.E108Q	DO15855	HNSC	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.5633
p.R92C	TCGA-CQ-A4CE	HNSC	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.R92C	DO233254	GACA	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.R92C	DO49071	HNSC	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.S426C	TCGA-FD-A62P	BLCA	TCGA	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.7541
p.S426C	DO44054	BLCA	ICGC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.7541
p.E421Q	DO228441	BRCA	ICGC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2778
p.A436D	DO223391	CLLE	ICGC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.0833
p.L93V	DO233218	GACA	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1389
p.E422K	DO222653	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.3056
p.R92H	DO232761	PBCA	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.A436V	DO229224	THCA	ICGC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.0833
p.A420P	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.A420P	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.R101T	SIDM00892	Breast Carcinoma	GDSC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7876
p.R101T	BT-483	breast	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7876
p.L104F	ACH-001628	Ovarian Cancer	CCLE	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6981
p.R115C	ACH-002052	Lung Cancer	CCLE	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation blocking phosphorylation signal	0.5833
p.R115C	LU-139	lung	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation blocking phosphorylation signal	0.5833
p.S109N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.E104D	NCI-H747	large intestine	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6758
p.S104N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7069
p.L422V	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.3056
p.A116V	YH-13	central nervous system	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.T420A	EHEB	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25

Kaplan plot for BAIAP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAIAP3

UniProt ID: O94812

Entrez ID: 8938

Protein name: BAI1-associated protein 3 (BAP3) (Brain-specific angiogenesis inhibitor I-associated protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BAIAP3 in