DegronMD

Uniprot ID: O94812

Source protein: BAI1-associated protein 3

Source gene: BAIAP3

Class: DEG_APCC_DBOX_1

Location: 100:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9904

ASA_SCORE: 78.0222

COIL: 0.7254

CONS_SCORE: 0.2459

DSS_SCORE: 0.4444

HELIX: 0.168

FCONS_SCORE: 0.9921

RIG_SCORE: 0.7135

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G98W	TCGA-62-8399	LUAD	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	0.2778
p.G98W	TCGA-F7-A620	HNSC	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	0.2778
p.G98W	DO44445	HNSC	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	0.2778
p.G98W	DO24606	LUAD	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	0.2778
p.E99K	TCGA-91-6836	LUAD	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	0.3056
p.E99K	DO23854	LUAD	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	0.3056
p.R112H	TCGA-AX-A2HD	UCEC	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	0.2222
p.R112H	DO42608	UCEC	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	0.2222
p.E108Q	TCGA-BB-4227	HNSC	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	0.5633
p.E108Q	DO15855	HNSC	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	0.5633
p.R92C	TCGA-CQ-A4CE	HNSC	TCGA	GRQGLPCLE	DEG_APCC_DBOX_1	0.1111
p.R92C	DO233254	GACA	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	0.1111
p.R92C	DO49071	HNSC	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	0.1111
p.L93V	DO233218	GACA	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	0.1389
p.R92H	DO232761	PBCA	ICGC	GRQGLPCLE	DEG_APCC_DBOX_1	0.1111
p.R101T	SIDM00892	Breast Carcinoma	GDSC	GRQGLPCLE	DEG_APCC_DBOX_1	0.7876
p.R101T	BT-483	breast	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	0.7876
p.L104F	ACH-001628	Ovarian Cancer	CCLE	GRQGLPCLE	DEG_APCC_DBOX_1	0.6981
p.R115C	ACH-002052	Lung Cancer	CCLE	GRQGLPCLE	DEG_APCC_DBOX_1	0.5833
p.R115C	LU-139	lung	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	0.5833
p.S109N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	0.3056
p.E104D	NCI-H747	large_intestine	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	0.6758
p.S104N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	0.7069
p.A116V	YH-13	central_nervous_system	COSMIC	GRQGLPCLE	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94812	BAI1-associated protein 3	DEG_APCC_DBOX_1	100:108	GRQGLPCLE	APC,CDC20,FZR1	0.9904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons