DegronMD - Q15434(RBMS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S54R	TCGA-12-0778	GBM	TCGA	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0833
p.S54R	DO11411	GBM	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0833
p.K55N	TCGA-AA-A00N	COAD	TCGA	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation substituting flanking lysine	0.1667
p.K55N	DO9876	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation substituting flanking lysine	0.1667
p.I367T	TCGA-AP-A0LL	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.1667
p.I367T	DO41446	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.1667
p.S376F	TCGA-AZ-4315	COAD	TCGA	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation altering degron motif	0.7982
p.S376F	DO8842	COAD	ICGC	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation altering degron motif	0.7982
p.Q387H	TCGA-DX-A6YS	SARC	TCGA	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.0556
p.Q387H	DO220005	SARC	ICGC	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.0556
p.S43N	TCGA-FI-A2D5	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7069
p.S43N	DO41331	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7069
p.P41H	TCGA-HU-A4H2	STAD	TCGA	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7694
p.P41H	DO47825	STAD	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7694
p.G49V	TCGA-XF-A9SJ	BLCA	TCGA	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222
p.G49V	DO219045	BLCA	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222
p.E41D	DO51878	BLCA	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.6758
p.R40P	DO219068	BLCA	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation blocking phosphorylation signal	0.75
p.E41K	DO225159	BRCA	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7022
p.E41K	DO227790	BRCA	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7022
p.Q52H	DO229029	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1389
p.V373L	DO229041	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation altering degron motif	0.6765
p.P32L	DO50955	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0833
p.P32L	DO37410	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0833
p.G51S	DO232017	ORCA	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1667
p.R40H	DO34696	PACA	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation blocking phosphorylation signal	0.75
p.K53N	DO36556	READ	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1111
p.T45I	DO51749	STAD	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7078
p.Y370N	DO229234	THCA	ICGC	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.25
p.K31N	DO42673	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0556
p.S377T	SIDM00040	Gastric Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation altering degron motif	0.6005
p.S377T	ACH-002202	Gastric Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation altering degron motif	0.6005
p.S377T	TMK-1	stomach	COSMIC	VPSSS	DEG_SPOP_SBC_1	373:377	Mutation altering degron motif	0.6005
p.N50S	SIDM01617	Endometrial Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1944
p.N50S	ACH-000994	Endometrial/Uterine Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBMS2

UniProt ID: Q15434

Entrez ID: 5939

Protein name: RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBMS2 in