DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PNSSS
Uniprot ID:
P49790
Source protein:
Nuclear pore complex protein Nup153
Source gene:
NUP153
Class:
DEG_SPOP_SBC_1
Location:
1389:1393
E3 ligase:
SPOP
DEGRON score:
0.9056
ASA_SCORE:
72.1
COIL:
0.8694
CONS_SCORE:
0.4143
DSS_SCORE:
0.4947
HELIX:
0.0746
FCONS_SCORE:
0.8602
RIG_SCORE:
0.6333
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A1382V
TCGA-A5-A1OF
UCEC
TCGA
PNSSS
DEG_SPOP_SBC_1
0.1389
p.A1382V
DO42568
UCEC
ICGC
PNSSS
DEG_SPOP_SBC_1
0.1389
p.S1391P
TCGA-AX-A2HC
UCEC
TCGA
PNSSS
DEG_SPOP_SBC_1
0.6752
p.S1391P
DO41572
UCEC
ICGC
PNSSS
DEG_SPOP_SBC_1
0.6752
p.T1401I
TCGA-BG-A3EW
UCEC
TCGA
PNSSS
DEG_SPOP_SBC_1
0.1111
p.T1401I
DO48172
UCEC
ICGC
PNSSS
DEG_SPOP_SBC_1
0.1111
p.F1395L
TCGA-D8-A27G
BRCA
TCGA
PNSSS
DEG_SPOP_SBC_1
0.2778
p.F1395L
DO5465
BRCA
ICGC
PNSSS
DEG_SPOP_SBC_1
0.2778
p.A1394T
DO233804
GACA
ICGC
PNSSS
DEG_SPOP_SBC_1
0.3056
p.T1392I
SIDM00867
Glioblastoma
GDSC
PNSSS
DEG_SPOP_SBC_1
0.7078
p.T1392I
DBTRG-05MG
central_nervous_system
COSMIC
PNSSS
DEG_SPOP_SBC_1
0.7078
p.G1393C
KNS-42
central_nervous_system
COSMIC
PNSSS
DEG_SPOP_SBC_1
0.76
p.G1393C
TGBC11TKB
stomach
COSMIC
PNSSS
DEG_SPOP_SBC_1
0.76
p.G1393C
OVISE
ovary
COSMIC
PNSSS
DEG_SPOP_SBC_1
0.76
p.G1393C
LU-99A
lung
COSMIC
PNSSS
DEG_SPOP_SBC_1
0.76
p.S1389L
BC-3
haematopoietic_and_lymphoid_tissue
COSMIC
PNSSS
DEG_SPOP_SBC_1
0.7667
Drug responses associated with NUP153 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PNSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15117
FYN-binding protein 1
DEG_SPOP_SBC_1
26:30
PNSSS
SPOP
0.994
More...
O60741
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
DEG_SPOP_SBC_1
7:11
PNSSS
SPOP
0.7976
More...
O75179
Ankyrin repeat domain-containing protein 17
DEG_SPOP_SBC_1
2093:2097
PNSSS
SPOP
0.9431
More...
O94812
BAI1-associated protein 3
DEG_SPOP_SBC_1
423:427
PNSSS
SPOP
0.6757
More...
P49790
Nuclear pore complex protein Nup153
DEG_SPOP_SBC_1
1389:1393
PNSSS
SPOP
0.9056
More...
P56177
Homeobox protein DLX-1
DEG_SPOP_SBC_1
218:222
PNSSS
SPOP
0.9889
More...
Q16666
Gamma-interferon-inducible protein 16
DEG_SPOP_SBC_1
177:181
PNSSS
SPOP
0.9508
More...
Q16832
Discoidin domain-containing receptor 2
DEG_SPOP_SBC_1
672:676
PNSSS
SPOP
0.678
More...
Q659A1
Little elongation complex subunit 2
DEG_SPOP_SBC_1
606:610
PNSSS
SPOP
0.9659
More...
Q7L7V1
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
DEG_SPOP_SBC_1
9:13
PNSSS
SPOP
0.6156
More...
Q86V97
Kelch repeat and BTB domain-containing protein 6
DEG_SPOP_SBC_1
315:319
PNSSS
SPOP
0.8742
More...
Q8IZQ8
Myocardin
DEG_SPOP_SBC_1
334:338
PNSSS
SPOP
0.9909
More...
Q8N9N5
Protein BANP
DEG_SPOP_SBC_1
338:342
PNSSS
SPOP
0.9929
More...
Q8NHG8
E3 ubiquitin-protein ligase ZNRF2
DEG_SPOP_SBC_1
104:108
PNSSS
SPOP
0.9921
More...
Q8WVZ9
Kelch repeat and BTB domain-containing protein 7
DEG_SPOP_SBC_1
315:319
PNSSS
SPOP
0.9389
More...
Q8WXX7
Autism susceptibility gene 2 protein
DEG_SPOP_SBC_1
1008:1012
PNSSS
SPOP
0.7835
More...
Q96N67
Dedicator of cytokinesis protein 7
DEG_SPOP_SBC_1
860:864
PNSSS
SPOP
0.9622
More...
Q9H1B7
Probable E3 ubiquitin-protein ligase IRF2BPL
DEG_SPOP_SBC_1
216:220
PNSSS
SPOP
0.9952
More...
Q9NQ87
Hairy/enhancer-of-split related with YRPW motif-like protein
DEG_SPOP_SBC_1
298:302
PNSSS
SPOP
0.9384
More...
Q9ULH7
Myocardin-related transcription factor B
DEG_SPOP_SBC_1
1056:1060
PNSSS
SPOP
0.9777
More...
Q15434
RNA-binding motif, single-stranded-interacting protein 2
DEG_SPOP_SBC_1
41:45
PNSSS
SPOP
0.6568
More...
Q9BXY5
Calcyphosin-2
DEG_SPOP_SBC_1
92:96
PNSSS
SPOP
0.9192
More...