DegronMD - Q9H1B7(IRF2BPL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G643R	TCGA-17-Z049	LUAD	TCGA	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.S652L	TCGA-2W-A8YY	CESC	TCGA	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.2778
p.S652L	DO223732	CESC	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.2778
p.A651V	TCGA-2W-A8YY	CESC	TCGA	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.A651V	DO223732	CESC	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.G643S	TCGA-43-3920	LUSC	TCGA	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.G643S	DO26445	LUSC	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.25
p.R229H	TCGA-AA-A01R	COAD	TCGA	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0833
p.R229H	DO7934	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0833
p.S318L	TCGA-AZ-4315	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.1389
p.S318L	TCGA-AZ-4315	COAD	TCGA	ASSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.S318L	DO8842	COAD	ICGC	ATSSS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.1389
p.S318L	DO8842	COAD	ICGC	ASSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.R655Q	TCGA-EO-A22R	UCEC	TCGA	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.R655Q	DO42713	UCEC	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.S227Y	TCGA-EO-A22R	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation blocking phosphorylation signal	0.5833
p.S227Y	DO42713	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation blocking phosphorylation signal	0.5833
p.P209T	TCGA-ER-A19T	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1389
p.P209T	DO51251	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1389
p.R654W	TCGA-L5-A4OR	ESCA	TCGA	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.2222
p.A651E	TCGA-ZB-A964	THYM	TCGA	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.A651E	DO229015	LICA	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.K641N	TCGA-ZG-A8QY	PRAD	TCGA	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation substituting flanking lysine	0.3056
p.K641N	DO51449	PRAD	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation substituting flanking lysine	0.3056
p.N212S	DO225030	BRCA	ICGC	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.2222
p.N212S	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.2222
p.N212S	ACH-000914	Lymphoma	CCLE	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.2222
p.N212S	HT	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.2222
p.A222G	DO229384	BTCA	ICGC	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.2778
p.A637T	DO227987	COCA	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.0833
p.H647N	DO228941	LICA	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6312
p.R229S	DO229028	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0833
p.N656K	DO229027	LICA	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1667
p.N656D	DO23124	LINC	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1667
p.G300R	DO228168	PBCA	ICGC	LGGTPGVS	DEG_SCF_FBW7_1	299:306	Mutation altering degron motif	0.6457
p.S659N	DO232224	PBCA	ICGC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation blocking phosphorylation signal	0.5278
p.G294W	DO229140	THCA	ICGC	LGGTPGVS	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1944
p.T649I	SIDM00425	Ovarian Carcinoma	GDSC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	SIDM00291	Melanoma	GDSC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	SIDM00251	Gastric Carcinoma	GDSC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	ACH-000408	Esophageal Cancer	CCLE	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	ACH-000663	Ovarian Cancer	CCLE	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	ACH-000949	Gastric Cancer	CCLE	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	ACH-002040	Skin Cancer	CCLE	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	HMV-II	skin	COSMIC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	OVTOKO	ovary	COSMIC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	TE-5	oesophagus	COSMIC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.T649I	TGBC11TKB	stomach	COSMIC	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7078
p.S313L	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.6556
p.S313L	SIDM00465	Ovarian Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.6556
p.S313L	LK-2	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.6556
p.S313L	OVMIU	ovary	COSMIC	ASSST	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.6556
p.V225G	ACH-000955	Colon/Colorectal Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1944
p.S314F	ACH-000979	Prostate Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.7982
p.V646M	ACH-001033	Unknown	CCLE	VHSTT	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7208
p.A307V	ACH-002256	Leukemia	CCLE	ATSSS	DEG_SPOP_SBC_1	307:311	Mutation altering degron motif	0.5825
p.A307V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	307:311	Mutation altering degron motif	0.5825

Kaplan plot for IRF2BPL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRF2BPL

UniProt ID: Q9H1B7

Entrez ID: 64207

Protein name: Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRF2BPL in