DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LGGTPGVS
Uniprot ID:
Q9H1B7
Source protein:
Probable E3 ubiquitin-protein ligase IRF2BPL
Source gene:
IRF2BPL
Class:
DEG_SCF_FBW7_1
Location:
299:306
E3 ligase:
FBXW7
DEGRON score:
0.9774
ASA_SCORE:
63.775
COIL:
0.9006
CONS_SCORE:
0.3015
DSS_SCORE:
0.5884
HELIX:
0.0563
FCONS_SCORE:
0.9824
RIG_SCORE:
0.6094
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G300R
DO228168
PBCA
ICGC
LGGTPGVS
DEG_SCF_FBW7_1
0.6457
p.G294W
DO229140
THCA
ICGC
LGGTPGVS
DEG_SCF_FBW7_1
0.1944
Drug responses associated with IRF2BPL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LGGTPGVS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H1B7
Probable E3 ubiquitin-protein ligase IRF2BPL
DEG_SCF_FBW7_1
299:306
LGGTPGVS
FBXW7
0.9774
More...