DegronMD

Uniprot ID: Q9H1B7

Source protein: Probable E3 ubiquitin-protein ligase IRF2BPL

Source gene: IRF2BPL

Class: DEG_SPOP_SBC_1

Location: 646:650

E3 ligase: SPOP

DEGRON score: 0.8179

ASA_SCORE: 81.9

COIL: 0.8676

CONS_SCORE: 0.2895

DSS_SCORE: 0.7199

HELIX: 0.0848

FCONS_SCORE: 0.8804

RIG_SCORE: 0.6267

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G643R	TCGA-17-Z049	LUAD	TCGA	VHSTT	DEG_SPOP_SBC_1	0.25
p.S652L	TCGA-2W-A8YY	CESC	TCGA	VHSTT	DEG_SPOP_SBC_1	0.2778
p.S652L	DO223732	CESC	ICGC	VHSTT	DEG_SPOP_SBC_1	0.2778
p.A651V	TCGA-2W-A8YY	CESC	TCGA	VHSTT	DEG_SPOP_SBC_1	0.3056
p.A651V	DO223732	CESC	ICGC	VHSTT	DEG_SPOP_SBC_1	0.3056
p.G643S	TCGA-43-3920	LUSC	TCGA	VHSTT	DEG_SPOP_SBC_1	0.25
p.G643S	DO26445	LUSC	ICGC	VHSTT	DEG_SPOP_SBC_1	0.25
p.R655Q	TCGA-EO-A22R	UCEC	TCGA	VHSTT	DEG_SPOP_SBC_1	0.1944
p.R655Q	DO42713	UCEC	ICGC	VHSTT	DEG_SPOP_SBC_1	0.1944
p.R654W	TCGA-L5-A4OR	ESCA	TCGA	VHSTT	DEG_SPOP_SBC_1	0.2222
p.A651E	TCGA-ZB-A964	THYM	TCGA	VHSTT	DEG_SPOP_SBC_1	0.3056
p.A651E	DO229015	LICA	ICGC	VHSTT	DEG_SPOP_SBC_1	0.3056
p.K641N	TCGA-ZG-A8QY	PRAD	TCGA	VHSTT	DEG_SPOP_SBC_1	0.3056
p.K641N	DO51449	PRAD	ICGC	VHSTT	DEG_SPOP_SBC_1	0.3056
p.A637T	DO227987	COCA	ICGC	VHSTT	DEG_SPOP_SBC_1	0.0833
p.H647N	DO228941	LICA	ICGC	VHSTT	DEG_SPOP_SBC_1	0.6312
p.N656K	DO229027	LICA	ICGC	VHSTT	DEG_SPOP_SBC_1	0.1667
p.N656D	DO23124	LINC	ICGC	VHSTT	DEG_SPOP_SBC_1	0.1667
p.S659N	DO232224	PBCA	ICGC	VHSTT	DEG_SPOP_SBC_1	0.5278
p.T649I	SIDM00425	Ovarian Carcinoma	GDSC	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	SIDM00291	Melanoma	GDSC	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	SIDM00251	Gastric Carcinoma	GDSC	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	ACH-000408	Esophageal Cancer	CCLE	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	ACH-000663	Ovarian Cancer	CCLE	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	ACH-000949	Gastric Cancer	CCLE	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	ACH-002040	Skin Cancer	CCLE	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	HMV-II	skin	COSMIC	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	OVTOKO	ovary	COSMIC	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	TE-5	oesophagus	COSMIC	VHSTT	DEG_SPOP_SBC_1	0.7078
p.T649I	TGBC11TKB	stomach	COSMIC	VHSTT	DEG_SPOP_SBC_1	0.7078
p.V646M	ACH-001033	Unknown	CCLE	VHSTT	DEG_SPOP_SBC_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5L9	Interferon regulatory factor 2-binding protein 2	DEG_SPOP_SBC_1	447:451	VHSTT	SPOP	0.9955	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	646:650	VHSTT	SPOP	0.8179	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VHSTT

Degron related mutations and impact score

Drug responses associated with IRF2BPL mutations

All proteins holding degron of VHSTT