DegronMD

Uniprot ID: Q7Z5L9

Source protein: Interferon regulatory factor 2-binding protein 2

Source gene: IRF2BP2

Class: DEG_SPOP_SBC_1

Location: 447:451

E3 ligase: SPOP

DEGRON score: 0.9955

ASA_SCORE: 87.8

COIL: 0.8328

CONS_SCORE: 0.3742

DSS_SCORE: 0.8081

HELIX: 0.1368

FCONS_SCORE: 1.0679

RIG_SCORE: 0.6311

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P458S	TCGA-04-1648	OV	TCGA	VHSTT	DEG_SPOP_SBC_1	0.1389
p.P458S	DO31584	OV	ICGC	VHSTT	DEG_SPOP_SBC_1	0.1389
p.G437D	TCGA-A5-A2K5	UCEC	TCGA	VHSTT	DEG_SPOP_SBC_1	0.0556
p.G437D	DO41379	UCEC	ICGC	VHSTT	DEG_SPOP_SBC_1	0.0556
p.G437D	SIDM00422	Hodgkin's Lymphoma	GDSC	VHSTT	DEG_SPOP_SBC_1	0.0556
p.G437D	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VHSTT	DEG_SPOP_SBC_1	0.0556
p.S438I	TCGA-AP-A051	UCEC	TCGA	VHSTT	DEG_SPOP_SBC_1	0.0833
p.S438I	DO42673	UCEC	ICGC	VHSTT	DEG_SPOP_SBC_1	0.0833
p.R453M	TCGA-IB-7651	PAAD	TCGA	VHSTT	DEG_SPOP_SBC_1	0.2778
p.R453M	DO46657	PAAD	ICGC	VHSTT	DEG_SPOP_SBC_1	0.2778
p.S455G	DO228813	LICA	ICGC	VHSTT	DEG_SPOP_SBC_1	0.6667
p.P459T	DO228971	LICA	ICGC	VHSTT	DEG_SPOP_SBC_1	0.1111
p.P461L	DO222875	MELA	ICGC	VHSTT	DEG_SPOP_SBC_1	0.0556
p.S457T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VHSTT	DEG_SPOP_SBC_1	0.6111
p.S457T	NCI-H650	lung	COSMIC	VHSTT	DEG_SPOP_SBC_1	0.6111
p.A444T	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	VHSTT	DEG_SPOP_SBC_1	0.25
p.S441T	ACH-000945	Lung Cancer	CCLE	VHSTT	DEG_SPOP_SBC_1	0.1667
p.S441T	NCI-H650	lung	COSMIC	VHSTT	DEG_SPOP_SBC_1	0.1667
p.Q450K	ACH-000983	Leukemia	CCLE	VHSTT	DEG_SPOP_SBC_1	0.6944
p.Q450K	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VHSTT	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5L9	Interferon regulatory factor 2-binding protein 2	DEG_SPOP_SBC_1	447:451	VHSTT	SPOP	0.9955	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	646:650	VHSTT	SPOP	0.8179	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons