DegronMD - Q7Z5L9(IRF2BP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P458S	TCGA-04-1648	OV	TCGA	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1389
p.P458S	DO31584	OV	ICGC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1389
p.P400L	TCGA-37-4133	LUSC	TCGA	IPMTPTSS	DEG_SCF_FBW7_1	389:396	Mutation rewiring degron network	0.2222
p.P400L	DO26465	LUSC	ICGC	IPMTPTSS	DEG_SCF_FBW7_1	389:396	Mutation rewiring degron network	0.2222
p.G437D	TCGA-A5-A2K5	UCEC	TCGA	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.0556
p.G437D	DO41379	UCEC	ICGC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.0556
p.G437D	SIDM00422	Hodgkin's Lymphoma	GDSC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.0556
p.G437D	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.0556
p.S438I	TCGA-AP-A051	UCEC	TCGA	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.0833
p.S438I	DO42673	UCEC	ICGC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.0833
p.M391V	TCGA-BA-A4II	HNSC	TCGA	IPMTPTSS	DEG_SCF_FBW7_1	389:396	Mutation altering degron motif	0.6097
p.M391V	DO52030	HNSC	ICGC	IPMTPTSS	DEG_SCF_FBW7_1	389:396	Mutation altering degron motif	0.6097
p.R453M	TCGA-IB-7651	PAAD	TCGA	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.2778
p.R453M	DO46657	PAAD	ICGC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.2778
p.T308S	DO52544	BRCA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	305:313	Mutation altering degron motif	0.6005
p.S455G	DO228813	LICA	ICGC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation blocking phosphorylation signal	0.6667
p.P459T	DO228971	LICA	ICGC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1111
p.H315Q	DO228985	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	305:313	Mutation rewiring degron network	0.2778
p.P302H	DO229019	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	305:313	Mutation rewiring degron network	0.25
p.D307E	DO229026	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	305:313	Mutation altering degron motif	0.5647
p.D307E	DO229009	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	305:313	Mutation altering degron motif	0.5647
p.P302T	DO229041	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	305:313	Mutation rewiring degron network	0.25
p.H315N	DO229008	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	305:313	Mutation rewiring degron network	0.2778
p.P461L	DO222875	MELA	ICGC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.0556
p.S457T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation blocking phosphorylation signal	0.6111
p.S457T	NCI-H650	lung	COSMIC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation blocking phosphorylation signal	0.6111
p.A444T	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.25
p.S383F	SIDM00168	Head and Neck Carcinoma	GDSC	IPMTPTSS	DEG_SCF_FBW7_1	389:396	Mutation blocking phosphorylation signal	0.6111
p.S441T	ACH-000945	Lung Cancer	CCLE	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1667
p.S441T	NCI-H650	lung	COSMIC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1667
p.Q450K	ACH-000983	Leukemia	CCLE	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.6944
p.Q450K	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VHSTT	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.6944
p.S393P	ACH-001664	Gastric Cancer	CCLE	IPMTPTSS	DEG_SCF_FBW7_1	389:396	Mutation altering degron motif	0.6752

Kaplan plot for IRF2BP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRF2BP2

UniProt ID: Q7Z5L9

Entrez ID: 359948

Protein name: Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRF2BP2 in