DegronMD

Uniprot ID: Q7Z5L9

Source protein: Interferon regulatory factor 2-binding protein 2

Source gene: IRF2BP2

Class: DEG_APCC_DBOX_1

Location: 305:313

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.992

ASA_SCORE: 53.8556

COIL: 0.4577

CONS_SCORE: 0.3901

DSS_SCORE: 0.5381

HELIX: 0.4757

FCONS_SCORE: 1.3614

RIG_SCORE: 0.7659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T308S	DO52544	BRCA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	0.6005
p.H315Q	DO228985	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	0.2778
p.P302H	DO229019	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	0.25
p.D307E	DO229026	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	0.5647
p.D307E	DO229009	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	0.5647
p.P302T	DO229041	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	0.25
p.H315N	DO229008	LICA	ICGC	VRDTLLALH	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5L9	Interferon regulatory factor 2-binding protein 2	DEG_APCC_DBOX_1	305:313	VRDTLLALH	APC,CDC20,FZR1	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons