DegronMD

Uniprot ID: Q7Z5L9

Source protein: Interferon regulatory factor 2-binding protein 2

Source gene: IRF2BP2

Class: DEG_SCF_FBW7_1

Location: 389:396

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 78.8875

COIL: 0.9256

CONS_SCORE: 0.3376

DSS_SCORE: 0.6755

HELIX: 0.0281

FCONS_SCORE: 1.1868

RIG_SCORE: 0.6393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P400L	TCGA-37-4133	LUSC	TCGA	IPMTPTSS	DEG_SCF_FBW7_1	0.2222
p.P400L	DO26465	LUSC	ICGC	IPMTPTSS	DEG_SCF_FBW7_1	0.2222
p.M391V	TCGA-BA-A4II	HNSC	TCGA	IPMTPTSS	DEG_SCF_FBW7_1	0.6097
p.M391V	DO52030	HNSC	ICGC	IPMTPTSS	DEG_SCF_FBW7_1	0.6097
p.S383F	SIDM00168	Head and Neck Carcinoma	GDSC	IPMTPTSS	DEG_SCF_FBW7_1	0.6111
p.S393P	ACH-001664	Gastric Cancer	CCLE	IPMTPTSS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5L9	Interferon regulatory factor 2-binding protein 2	DEG_SCF_FBW7_1	389:396	IPMTPTSS	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons