DegronMD - P16989(YBX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G136R	TCGA-70-6723	LUSC	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation altering degron motif	0.6457
p.G136R	DO26882	LUSC	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation altering degron motif	0.6457
p.E139K	TCGA-77-7337	LUSC	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation rewiring degron network	0.25
p.E139K	DO27445	LUSC	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation rewiring degron network	0.25
p.R129Q	TCGA-AX-A2HC	UCEC	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation altering degron motif	0.7329
p.R129Q	DO41572	UCEC	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation altering degron motif	0.7329
p.V145A	TCGA-VQ-A8P2	STAD	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation rewiring degron network	0.0833
p.V145A	DO51761	STAD	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation rewiring degron network	0.0833
p.D137V	DO234236	ESAD	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation rewiring degron network	0.3056
p.R133S	DO228971	LICA	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation altering degron motif	0.6316
p.I123M	SIDM00352	Ovarian Carcinoma	GDSC	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation rewiring degron network	0.1944
p.I123M	ACH-000719	Ovarian Cancer	CCLE	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation rewiring degron network	0.1944
p.I123M	RMG-I	ovary	COSMIC	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation rewiring degron network	0.1944
p.T14A	ACH-000990	Endometrial/Uterine Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	7:11	Mutation blocking phosphorylation signal	0.6944
p.N127S	ACH-001786	Colon/Colorectal Cancer	CCLE	PRKYLRSVG	DEG_APCC_DBOX_1	128:136	Mutation rewiring degron network	0.3056

Kaplan plot for YBX3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

YBX3

UniProt ID: P16989

Entrez ID: 8531

Protein name: Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for YBX3 in