DegronMD

Uniprot ID: P16989

Source protein: Y-box-binding protein 3

Source gene: YBX3

Class: DEG_APCC_DBOX_1

Location: 128:136

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9571

ASA_SCORE: 68.5222

COIL: 0.5938

CONS_SCORE: 0.6277

DSS_SCORE: 0.434

HELIX: 0.0494

FCONS_SCORE: 0.846

RIG_SCORE: 0.7573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G136R	TCGA-70-6723	LUSC	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	0.6457
p.G136R	DO26882	LUSC	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.6457
p.E139K	TCGA-77-7337	LUSC	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	0.25
p.E139K	DO27445	LUSC	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.25
p.R129Q	TCGA-AX-A2HC	UCEC	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	0.7329
p.R129Q	DO41572	UCEC	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.7329
p.V145A	TCGA-VQ-A8P2	STAD	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	0.0833
p.V145A	DO51761	STAD	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.0833
p.D137V	DO234236	ESAD	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.3056
p.R133S	DO228971	LICA	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.6316
p.I123M	SIDM00352	Ovarian Carcinoma	GDSC	PRKYLRSVG	DEG_APCC_DBOX_1	0.1944
p.I123M	ACH-000719	Ovarian Cancer	CCLE	PRKYLRSVG	DEG_APCC_DBOX_1	0.1944
p.I123M	RMG-I	ovary	COSMIC	PRKYLRSVG	DEG_APCC_DBOX_1	0.1944
p.N127S	ACH-001786	Colon/Colorectal Cancer	CCLE	PRKYLRSVG	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons