DegronMD

Uniprot ID: P67809

Source protein: Y-box-binding protein 1

Source gene: YBX1

Class: DEG_APCC_DBOX_1

Location: 96:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9781

ASA_SCORE: 70.6667

COIL: 0.6224

CONS_SCORE: 0.6442

DSS_SCORE: 0.4307

HELIX: 0.046

FCONS_SCORE: 0.86

RIG_SCORE: 0.7582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R101C	TCGA-22-5477	LUSC	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	0.719
p.R101C	TCGA-EY-A549	UCEC	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	0.719
p.R101C	DO26894	LUSC	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.719
p.R101C	DO48174	UCEC	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.719
p.A90V	TCGA-A8-A09Z	BRCA	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	0.1667
p.A90V	DO5521	BRCA	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.1667
p.R97M	TCGA-DF-A2KN	UCEC	TCGA	PRKYLRSVG	DEG_APCC_DBOX_1	0.8632
p.R97M	DO223282	UCEC	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.8632
p.D105G	DO23504	LINC	ICGC	PRKYLRSVG	DEG_APCC_DBOX_1	0.3056
p.S102I	SIDM00373	Endometrial Carcinoma	GDSC	PRKYLRSVG	DEG_APCC_DBOX_1	0.7341
p.S102I	ACH-000974	Endometrial/Uterine Cancer	CCLE	PRKYLRSVG	DEG_APCC_DBOX_1	0.7341
p.I91V	SIDM00567	Other Solid Cancers	GDSC	PRKYLRSVG	DEG_APCC_DBOX_1	0.1944
p.I91V	ACH-000776	Brain Cancer	CCLE	PRKYLRSVG	DEG_APCC_DBOX_1	0.1944
p.I91V	ONS-76	central_nervous_system	COSMIC	PRKYLRSVG	DEG_APCC_DBOX_1	0.1944
p.N95I	SIDM00628	Breast Carcinoma	GDSC	PRKYLRSVG	DEG_APCC_DBOX_1	0.3056
p.N95I	ACH-000849	Breast Cancer	CCLE	PRKYLRSVG	DEG_APCC_DBOX_1	0.3056
p.N95I	MDA-MB-468	breast	COSMIC	PRKYLRSVG	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons