DegronMD - Q9H347(UBQLN3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S308T	TCGA-06-0686	GBM	TCGA	PWTST	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.6005
p.S308T	DO13348	GBM	ICGC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.6005
p.S294L	TCGA-34-2605	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.2222
p.S294L	DO26471	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.2222
p.A286T	TCGA-AD-A5EJ	COAD	TCGA	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7139
p.A286T	DO50090	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7139
p.N276T	TCGA-B7-5818	STAD	TCGA	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.N276T	DO38883	STAD	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.G318E	TCGA-BF-A1Q0	SKCM	TCGA	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.G318E	DO222708	MELA	ICGC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.G318E	DO47374	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.G318E	SIDM01175	Other Sarcomas	GDSC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.G318E	ACH-002309	Sarcoma	CCLE	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.G318E	SW684	soft tissue	COSMIC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.S315I	TCGA-BR-8591	STAD	TCGA	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1667
p.S315I	DO47973	STAD	ICGC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1667
p.G318R	TCGA-D3-A3ML	SKCM	TCGA	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.G318R	DO47413	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.P277S	TCGA-D3-A8GI	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0833
p.P277S	DO50284	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0833
p.R295M	TCGA-EO-A22X	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1944
p.R295M	TCGA-EO-A22X	UCEC	TCGA	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0556
p.R295M	DO43907	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1944
p.R295M	DO43907	UCEC	ICGC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0556
p.D300H	TCGA-JW-A5VL	CESC	TCGA	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.D300H	TCGA-JW-A5VL	CESC	TCGA	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1944
p.D300H	DO49976	CESC	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.D300H	DO49976	CESC	ICGC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1944
p.P277L	TCGA-MP-A4T7	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0833
p.P277L	TCGA-W3-A824	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0833
p.P277L	DO45370	LUAD	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0833
p.P277L	DO51271	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0833
p.G312A	TCGA-NC-A5HG	LUSC	TCGA	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.25
p.G312A	DO45448	LUSC	ICGC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.25
p.F278V	TCGA-XF-A8HG	BLCA	TCGA	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1111
p.F278V	DO49802	BLCA	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1111
p.T290S	DO229010	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.6005
p.T290S	DO229016	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.6005
p.T290S	DO229489	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.6005
p.T290S	DO52365	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.6005
p.E297Q	DO44800	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1389
p.E297Q	DO44800	LICA	ICGC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1111
p.P293L	DO222699	MELA	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.25
p.N298S	DO233295	NACA	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1111
p.N298S	DO233295	NACA	ICGC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1389
p.T282A	DO233299	NACA	ICGC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.2222
p.N285D	SIDM00969	Ovarian Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.3056
p.N285D	SIDM00319	Melanoma	GDSC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.3056
p.N285D	SIDM00277	Acute Myeloid Leukemia	GDSC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.3056
p.N285D	SIDM01229	Neuroblastoma	GDSC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.3056
p.N285D	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.3056
p.N285D	SIDM01387	Small Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.3056
p.T288S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.6005
p.T288S	HARA	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.6005
p.L302P	SIDM00889	Cervical Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.25
p.L302P	ACH-001333	Cervical Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.25
p.L302P	C-33-A	cervix	COSMIC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.25
p.G318V	SIDM01118	Small Cell Lung Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.G318V	ACH-002175	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.G318V	NCI-H740	lung	COSMIC	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.P293H	SIDM01182	Bladder Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.25
p.P293H	ACH-000522	Bladder Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.25
p.P293H	UM-UC-3	urinary tract	COSMIC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.25
p.T288I	SIDM00591	Oral Cavity Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7078
p.T288I	ACH-002045	Head and Neck Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7078
p.T288I	HO-1-u-1	upper aerodigestive tract	COSMIC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7078
p.G314V	ACH-000515	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1944
p.D284N	ACH-002396	Bone Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.2778
p.D284N	Sarc9371	bone	COSMIC	ATTTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBQLN3

UniProt ID: Q9H347

Entrez ID: 50613

Protein name: Ubiquilin-3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBQLN3 in