DegronMD

Uniprot ID: Q9H347

Source protein: Ubiquilin-3

Source gene: UBQLN3

Class: DEG_SPOP_SBC_1

Location: 305:309

E3 ligase: SPOP

DEGRON score: 0.9862

ASA_SCORE: 65.38

COIL: 0.8698

CONS_SCORE: 0.5528

DSS_SCORE: 0.7299

HELIX: 0.069

FCONS_SCORE: 1.4011

RIG_SCORE: 0.6118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S308T	TCGA-06-0686	GBM	TCGA	PWTST	DEG_SPOP_SBC_1	0.6005
p.S308T	DO13348	GBM	ICGC	PWTST	DEG_SPOP_SBC_1	0.6005
p.G318E	TCGA-BF-A1Q0	SKCM	TCGA	PWTST	DEG_SPOP_SBC_1	0.0833
p.G318E	DO222708	MELA	ICGC	PWTST	DEG_SPOP_SBC_1	0.0833
p.G318E	DO47374	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	0.0833
p.G318E	SIDM01175	Other Sarcomas	GDSC	PWTST	DEG_SPOP_SBC_1	0.0833
p.G318E	ACH-002309	Sarcoma	CCLE	PWTST	DEG_SPOP_SBC_1	0.0833
p.G318E	SW684	soft_tissue	COSMIC	PWTST	DEG_SPOP_SBC_1	0.0833
p.S315I	TCGA-BR-8591	STAD	TCGA	PWTST	DEG_SPOP_SBC_1	0.1667
p.S315I	DO47973	STAD	ICGC	PWTST	DEG_SPOP_SBC_1	0.1667
p.G318R	TCGA-D3-A3ML	SKCM	TCGA	PWTST	DEG_SPOP_SBC_1	0.0833
p.G318R	DO47413	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	0.0833
p.R295M	TCGA-EO-A22X	UCEC	TCGA	PWTST	DEG_SPOP_SBC_1	0.0556
p.R295M	DO43907	UCEC	ICGC	PWTST	DEG_SPOP_SBC_1	0.0556
p.D300H	TCGA-JW-A5VL	CESC	TCGA	PWTST	DEG_SPOP_SBC_1	0.1944
p.D300H	DO49976	CESC	ICGC	PWTST	DEG_SPOP_SBC_1	0.1944
p.G312A	TCGA-NC-A5HG	LUSC	TCGA	PWTST	DEG_SPOP_SBC_1	0.25
p.G312A	DO45448	LUSC	ICGC	PWTST	DEG_SPOP_SBC_1	0.25
p.E297Q	DO44800	LICA	ICGC	PWTST	DEG_SPOP_SBC_1	0.1111
p.N298S	DO233295	NACA	ICGC	PWTST	DEG_SPOP_SBC_1	0.1389
p.L302P	SIDM00889	Cervical Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	0.25
p.L302P	ACH-001333	Cervical Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	0.25
p.L302P	C-33-A	cervix	COSMIC	PWTST	DEG_SPOP_SBC_1	0.25
p.G318V	SIDM01118	Small Cell Lung Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	0.0833
p.G318V	ACH-002175	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	0.0833
p.G318V	NCI-H740	lung	COSMIC	PWTST	DEG_SPOP_SBC_1	0.0833
p.G314V	ACH-000515	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13140:13144	PWTST	SPOP	0.9951	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	473:477	PWTST	SPOP	0.9067	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	305:309	PWTST	SPOP	0.9862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons