DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 13140:13144

E3 ligase: SPOP

DEGRON score: 0.9951

ASA_SCORE: 73.86

COIL: 0.727

CONS_SCORE: 0

DSS_SCORE: 0.5047

HELIX: 0.0444

FCONS_SCORE: 0

RIG_SCORE: 0.7456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H13130N	TCGA-17-Z061	LUAD	TCGA	PWTST	DEG_SPOP_SBC_1	0.0556
p.R13131W	TCGA-EB-A41A	SKCM	TCGA	PWTST	DEG_SPOP_SBC_1	0.0833
p.R13131W	DO37429	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	0.0833
p.V13145L	TCGA-EE-A2GB	SKCM	TCGA	PWTST	DEG_SPOP_SBC_1	0.3056
p.V13145L	DO222683	MELA	ICGC	PWTST	DEG_SPOP_SBC_1	0.3056
p.V13145L	DO37417	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	0.3056
p.L13147I	DO229032	LICA	ICGC	PWTST	DEG_SPOP_SBC_1	0.25
p.L13147I	DO50788	LICA	ICGC	PWTST	DEG_SPOP_SBC_1	0.25
p.S13132T	DO229052	LICA	ICGC	PWTST	DEG_SPOP_SBC_1	0.5556
p.T13139P	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	PWTST	DEG_SPOP_SBC_1	0.3056
p.G13134V	ACH-000563	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13140:13144	PWTST	SPOP	0.9951	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	473:477	PWTST	SPOP	0.9067	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	305:309	PWTST	SPOP	0.9862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons