DegronMD

Uniprot ID: Q9HBB8

Source protein: Cadherin-related family member 5

Source gene: CDHR5

Class: DEG_SPOP_SBC_1

Location: 473:477

E3 ligase: SPOP

DEGRON score: 0.9067

ASA_SCORE: 74.3

COIL: 0.6004

CONS_SCORE: 0.6481

DSS_SCORE: 0.8496

HELIX: 0.017

FCONS_SCORE: 1.18

RIG_SCORE: 0.614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R483I	TCGA-ER-A2NF	SKCM	TCGA	PWTST	DEG_SPOP_SBC_1	0.1667
p.R483I	DO47451	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	0.1667
p.S464W	DO51900	BLCA	ICGC	PWTST	DEG_SPOP_SBC_1	0.0833
p.E465D	DO8618	COAD	ICGC	PWTST	DEG_SPOP_SBC_1	0.1111
p.V480G	DO229510	SKCA	ICGC	PWTST	DEG_SPOP_SBC_1	0.25
p.G479E	DO37667	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	0.2778
p.G479R	DO37667	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	0.2778
p.G479R	HuO-3N1	bone	COSMIC	PWTST	DEG_SPOP_SBC_1	0.2778
p.G479R	MKN1	stomach	COSMIC	PWTST	DEG_SPOP_SBC_1	0.2778
p.E465K	DO37831	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	0.1111
p.A483V	DO43041	UCEC	ICGC	PWTST	DEG_SPOP_SBC_1	0.1667
p.A483V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PWTST	DEG_SPOP_SBC_1	0.1667
p.T475A	SIDM00216	Colorectal Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	0.7139
p.T475A	ACH-000989	Colon/Colorectal Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	0.7139
p.V481I	SIDM00965	Small Cell Lung Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	0.2222
p.V481I	ACH-000800	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	0.2222
p.V481I	NCI-H446	lung	COSMIC	PWTST	DEG_SPOP_SBC_1	0.2222
p.P482L	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	0.1944
p.P482L	ACH-000904	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	0.1944
p.P482L	ACH-001362	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	0.1944
p.P482H	SIDM01617	Endometrial Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	0.1944
p.P482H	ACH-000994	Endometrial/Uterine Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13140:13144	PWTST	SPOP	0.9951	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	473:477	PWTST	SPOP	0.9067	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	305:309	PWTST	SPOP	0.9862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons