DegronMD

Uniprot ID: P05067

Source protein: Amyloid-beta precursor protein

Source gene: APP

Class: DEG_SPOP_SBC_1

Location: 273:277

E3 ligase: SPOP

DEGRON score: 0.8121

ASA_SCORE: 85.5

COIL: 0.8864

CONS_SCORE: 0.2984

DSS_SCORE: 0.6794

HELIX: 0.0482

FCONS_SCORE: 0.9799

RIG_SCORE: 0.7255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E285Q	TCGA-AC-A23H	BRCA	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1111
p.E284K	TCGA-EE-A29D	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1389
p.T274A	TCGA-EY-A2OM	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.6028
p.T274A	ACH-000963	Colon/Colorectal Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.6028
p.A273T	TCGA-IB-7651	PAAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.7139
p.E263K	TCGA-SJ-A6ZI	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0556
p.E263K	ACH-001356	Thyroid Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.0556
p.R287C	DO8264	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0556
p.N276S	DO46330	OV	ICGC	ATTTT	DEG_SPOP_SBC_1	0.7069
p.A284T	DO223286	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1389
p.M275V	EN	endometrium	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.7208
p.K285N	SK-MES-1	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.1111
p.E286K	EPLC-272H	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.0833
p.R283Q	COR-L105	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.1667
p.Q277H	CW-2	large_intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.7582
p.H278Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.K264N	SK-MES-1	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1536:1540	ATTTT	SPOP	0.9967	More...
O94856	Neurofascin	DEG_SPOP_SBC_1	1079:1083	ATTTT	SPOP	0.901	More...
O95500	Claudin-14	DEG_SPOP_SBC_1	200:204	ATTTT	SPOP	0.8725	More...
P05067	Amyloid-beta precursor protein	DEG_SPOP_SBC_1	273:277	ATTTT	SPOP	0.8121	More...
P16989	Y-box-binding protein 3	DEG_SPOP_SBC_1	7:11	ATTTT	SPOP	0.9812	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	830:834	ATTTT	SPOP	0.9992	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	264:268	ATTTT	SPOP	0.979	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	689:693	ATTTT	SPOP	0.8785	More...
P58401	Neurexin-2-beta	DEG_SPOP_SBC_1	327:331	ATTTT	SPOP	0.9847	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	614:618	ATTTT	SPOP	0.9958	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	43:47	ATTTT	SPOP	0.8865	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	1509:1513	ATTTT	SPOP	0.9091	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	160:164	ATTTT	SPOP	0.51	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1619:1623	ATTTT	SPOP	0.9887	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	289:293	ATTTT	SPOP	0.986	More...
Q9NXI6	E3 ubiquitin-protein ligase RNF186	DEG_SPOP_SBC_1	17:21	ATTTT	SPOP	0.7472	More...
Q9P2S2	Neurexin-2	DEG_SPOP_SBC_1	1373:1377	ATTTT	SPOP	0.9995	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1294:1298	ATTTT	SPOP	0.9994	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2393:2397	ATTTT	SPOP	0.9763	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	286:290	ATTTT	SPOP	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTTT

Degron related mutations and impact score

Drug responses associated with APP mutations

All proteins holding degron of ATTTT