DegronMD - P54727(RAD23B)

FUNCTION: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T181A	TCGA-69-7765	LUAD	TCGA	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.2778
p.T181A	DO23580	LUAD	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.2778
p.A124E	TCGA-91-6828	LUAD	TCGA	APTST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.2778
p.A124E	DO26150	LUAD	ICGC	APTST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.2778
p.A98S	TCGA-A5-A1OF	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	98:102	Mutation altering degron motif	0.7588
p.A98S	DO42568	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	98:102	Mutation altering degron motif	0.7588
p.T186M	TCGA-AA-A010	COAD	TCGA	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.1389
p.T186M	TCGA-BR-4362	STAD	TCGA	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.1389
p.T186M	DO38336	STAD	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.1389
p.T186M	SIDM02026	Colorectal Carcinoma	GDSC	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.1389
p.P115H	TCGA-AD-5900	COAD	TCGA	APTST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.25
p.P115H	DO8514	COAD	ICGC	APTST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.25
p.P156S	TCGA-AP-A059	UCEC	TCGA	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation altering degron motif	0.6752
p.P156S	DO41361	UCEC	ICGC	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation altering degron motif	0.6752
p.E150K	TCGA-C5-A1BL	CESC	TCGA	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2778
p.E150K	DO48986	CESC	ICGC	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2778
p.P113H	TCGA-DF-A2KU	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.1944
p.P113H	DO223286	UCEC	ICGC	APTST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.1944
p.L176I	TCGA-EE-A20F	SKCM	TCGA	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation altering degron motif	0.6063
p.L176I	DO37961	SKCM	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation altering degron motif	0.6063
p.S271Y	TCGA-EO-A3AY	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.25
p.S271Y	DO43202	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.25
p.P275L	TCGA-ER-A195	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1389
p.P275L	DO47712	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1389
p.S189Y	TCGA-FW-A3R5	SKCM	TCGA	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.0556
p.S189Y	DO37406	SKCM	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.0556
p.P152A	TCGA-RD-A8N6	STAD	TCGA	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation altering degron motif	0.7503
p.P152A	DO50140	STAD	ICGC	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation altering degron motif	0.7503
p.T263I	TCGA-VQ-A91S	STAD	TCGA	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.3056
p.T263I	DO222352	STAD	ICGC	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.3056
p.T262M	TCGA-YZ-A985	UVM	TCGA	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2778
p.D170G	DO233227	GACA	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.25
p.T87A	DO228597	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.1667
p.A94S	DO229015	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.6477
p.A94S	SIDM00567	Other Solid Cancers	GDSC	PASTT	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.6477
p.A94S	ACH-000776	Brain Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.6477
p.A94S	ONS-76	central nervous system	COSMIC	PASTT	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.6477
p.A116S	DO229022	LICA	ICGC	APTST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.2778
p.A163S	DO229035	LICA	ICGC	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2222
p.A163S	DO229035	LICA	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.0556
p.R173L	DO229035	LICA	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation altering degron motif	0.8428
p.A264S	DO229041	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.7588
p.P85L	DO229052	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.1111
p.S270R	SIDM02021	Esophageal Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2778
p.S168L	SIDM01198	Burkitt's Lymphoma	GDSC	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.S168L	SIDM01198	Burkitt's Lymphoma	GDSC	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.1944
p.S168L	ACH-000567	Lymphoma	CCLE	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.S168L	ACH-000567	Lymphoma	CCLE	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.1944
p.S168L	ST486	haematopoietic and lymphoid tissue	COSMIC	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.S168L	ST486	haematopoietic and lymphoid tissue	COSMIC	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation rewiring degron network	0.1944
p.A257G	SIDM00776	Colorectal Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1389
p.A257G	SIDM00359	Colorectal Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1389
p.T120I	SIDM00516	Melanoma	GDSC	APTST	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.7078
p.T120I	MZ7-mel	skin	COSMIC	APTST	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.7078
p.A131V	SIDM01446	Glioblastoma	GDSC	APTST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.0833
p.T164I	ACH-000976	Bile Duct Cancer	CCLE	PAETPVAT	DEG_SCF_FBW7_1	152:159	Mutation blocking phosphorylation signal	0.6389
p.T164I	ACH-000976	Bile Duct Cancer	CCLE	RSNLFED	LIG_APCC_ABBAyCdc20_2	173:179	Mutation blocking phosphorylation signal	0.5278
p.A263D	HCT-116	large intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.3056
p.S96L	ST486	haematopoietic and lymphoid tissue	COSMIC	PASTT	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.7667

Kaplan plot for RAD23B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAD23B

UniProt ID: P54727

Entrez ID: 5887

Protein name: UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAD23B in