DegronMD

Uniprot ID: P54727

Source protein: UV excision repair protein RAD23 homolog B

Source gene: RAD23B

Class: DEG_SCF_FBW7_1

Location: 152:159

E3 ligase: FBXW7

DEGRON score: 0.9908

ASA_SCORE: 90.3

COIL: 0.9203

CONS_SCORE: 0.2976

DSS_SCORE: 0.7458

HELIX: 0.0296

FCONS_SCORE: 1.0116

RIG_SCORE: 0.6113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P156S	TCGA-AP-A059	UCEC	TCGA	PAETPVAT	DEG_SCF_FBW7_1	0.6752
p.P156S	DO41361	UCEC	ICGC	PAETPVAT	DEG_SCF_FBW7_1	0.6752
p.E150K	TCGA-C5-A1BL	CESC	TCGA	PAETPVAT	DEG_SCF_FBW7_1	0.2778
p.E150K	DO48986	CESC	ICGC	PAETPVAT	DEG_SCF_FBW7_1	0.2778
p.P152A	TCGA-RD-A8N6	STAD	TCGA	PAETPVAT	DEG_SCF_FBW7_1	0.7503
p.P152A	DO50140	STAD	ICGC	PAETPVAT	DEG_SCF_FBW7_1	0.7503
p.A163S	DO229035	LICA	ICGC	PAETPVAT	DEG_SCF_FBW7_1	0.2222
p.S168L	SIDM01198	Burkitt's Lymphoma	GDSC	PAETPVAT	DEG_SCF_FBW7_1	0.0833
p.S168L	ACH-000567	Lymphoma	CCLE	PAETPVAT	DEG_SCF_FBW7_1	0.0833
p.S168L	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	PAETPVAT	DEG_SCF_FBW7_1	0.0833
p.T164I	ACH-000976	Bile Duct Cancer	CCLE	PAETPVAT	DEG_SCF_FBW7_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54727	UV excision repair protein RAD23 homolog B	DEG_SCF_FBW7_1	152:159	PAETPVAT	FBXW7	0.9908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons