DegronMD

Uniprot ID: P54727

Source protein: UV excision repair protein RAD23 homolog B

Source gene: RAD23B

Class: LIG_APCC_ABBAyCdc20_2

Location: 173:179

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.755

ASA_SCORE: 87.1286

COIL: 0.3927

CONS_SCORE: 0.2254

DSS_SCORE: 0.5346

HELIX: 0.5774

FCONS_SCORE: 0.6574

RIG_SCORE: 0.7137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T181A	TCGA-69-7765	LUAD	TCGA	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.2778
p.T181A	DO23580	LUAD	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.2778
p.T186M	TCGA-AA-A010	COAD	TCGA	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.T186M	TCGA-BR-4362	STAD	TCGA	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.T186M	DO38336	STAD	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.T186M	SIDM02026	Colorectal Carcinoma	GDSC	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.L176I	TCGA-EE-A20F	SKCM	TCGA	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.6063
p.L176I	DO37961	SKCM	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.6063
p.S189Y	TCGA-FW-A3R5	SKCM	TCGA	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.0556
p.S189Y	DO37406	SKCM	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.0556
p.D170G	DO233227	GACA	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.25
p.A163S	DO229035	LICA	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.0556
p.R173L	DO229035	LICA	ICGC	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.8428
p.S168L	SIDM01198	Burkitt's Lymphoma	GDSC	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.S168L	ACH-000567	Lymphoma	CCLE	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.S168L	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.T164I	ACH-000976	Bile Duct Cancer	CCLE	RSNLFED	LIG_APCC_ABBAyCdc20_2	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54727	UV excision repair protein RAD23 homolog B	LIG_APCC_ABBAyCdc20_2	173:179	RSNLFED	APC,CDC20,FZR1	0.755	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons