DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AVTSS
Uniprot ID:
P54727
Source protein:
UV excision repair protein RAD23 homolog B
Source gene:
RAD23B
Class:
DEG_SPOP_SBC_1
Location:
98:102
E3 ligase:
SPOP
DEGRON score:
0.9759
ASA_SCORE:
82.58
COIL:
0.923
CONS_SCORE:
0.1441
DSS_SCORE:
0.5185
HELIX:
0.044
FCONS_SCORE:
0.7571
RIG_SCORE:
0.6701
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A98S
TCGA-A5-A1OF
UCEC
TCGA
AVTSS
DEG_SPOP_SBC_1
0.7588
p.A98S
DO42568
UCEC
ICGC
AVTSS
DEG_SPOP_SBC_1
0.7588
Drug responses associated with RAD23B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AVTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P15822
Zinc finger protein 40
DEG_SPOP_SBC_1
329:333
AVTSS
SPOP
0.9756
More...
P54727
UV excision repair protein RAD23 homolog B
DEG_SPOP_SBC_1
98:102
AVTSS
SPOP
0.9759
More...
Q15811
Intersectin-1
DEG_SPOP_SBC_1
837:841
AVTSS
SPOP
0.9768
More...
Q5TCY1
Tau-tubulin kinase 1
DEG_SPOP_SBC_1
917:921
AVTSS
SPOP
0.9878
More...
Q6WCQ1
Myosin phosphatase Rho-interacting protein
DEG_SPOP_SBC_1
176:180
AVTSS
SPOP
0.9872
More...
Q6ZNA4
E3 ubiquitin-protein ligase Arkadia
DEG_SPOP_SBC_1
428:432
AVTSS
SPOP
0.9917
More...
Q9HCM4
Band 4.1-like protein 5
DEG_SPOP_SBC_1
709:713
AVTSS
SPOP
0.6181
More...
Q9UGI9
5'-AMP-activated protein kinase subunit gamma-3
DEG_SPOP_SBC_1
41:45
AVTSS
SPOP
0.9578
More...
Q5T9C9
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
DEG_SPOP_SBC_1
22:26
AVTSS
SPOP
0.6064
More...
Q8N5C6
S1 RNA-binding domain-containing protein 1
DEG_SPOP_SBC_1
791:795
AVTSS
SPOP
0.801
More...