DegronMD - Q5T9C9(PIP5KL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R28W	TCGA-CM-4746	COAD	TCGA	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.R28W	DO7882	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.A22S	TCGA-E6-A1LX	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7588
p.A22S	DO41020	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7588
p.E21K	DO9812	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.3056
p.R24H	DO48192	ESCA	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.8244
p.S23R	DO229046	LICA	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7427
p.P30T	DO26987	LUSC	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2222
p.G19E	DO220886	MELA	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P34S	DO50299	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.C20Y	DO38487	STAD	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.R33C	DO229253	THCA	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1389
p.R33C	DO229211	THCA	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1389
p.D27N	DO229100	UTCA	ICGC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.3056
p.A18T	SIDM00664	Pancreatic Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2222
p.R33L	ACH-000916	Lung Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1389
p.G32S	EMC-BAC-1	lung	COSMIC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1667
p.R14K	RC-K8	haematopoietic and lymphoid tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111

Kaplan plot for PIP5KL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIP5KL1

UniProt ID: Q5T9C9

Entrez ID: 138429

Protein name: Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PI(4)P 5-kinase-like protein 1) (PtdIns(4)P-5-kinase-like protein 1) (EC 2.7.1.68)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIP5KL1 in