DegronMD

Uniprot ID: P15822

Source protein: Zinc finger protein 40

Source gene: HIVEP1

Class: DEG_SPOP_SBC_1

Location: 329:333

E3 ligase: SPOP

DEGRON score: 0.9756

ASA_SCORE: 73.74

COIL: 0.7666

CONS_SCORE: 0.3369

DSS_SCORE: 0.3686

HELIX: 0.1714

FCONS_SCORE: 1.0581

RIG_SCORE: 0.7715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S340C	TCGA-BR-7704	STAD	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1389
p.S340C	DO38360	STAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.V325A	TCGA-FB-A5VM	PAAD	TCGA	AVTSS	DEG_SPOP_SBC_1	0.2222
p.V325A	DO49401	PAAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.2222
p.P339L	TCGA-FW-A3R5	SKCM	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1667
p.P339L	DO37406	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1667
p.V334A	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.3056
p.V334A	ACH-000021	Lung Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	0.3056
p.V334A	NCI-H1693	lung	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.3056
p.A320P	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	329:333	AVTSS	SPOP	0.9756	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	98:102	AVTSS	SPOP	0.9759	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	837:841	AVTSS	SPOP	0.9768	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	917:921	AVTSS	SPOP	0.9878	More...
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_SPOP_SBC_1	176:180	AVTSS	SPOP	0.9872	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	428:432	AVTSS	SPOP	0.9917	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	709:713	AVTSS	SPOP	0.6181	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	41:45	AVTSS	SPOP	0.9578	More...
Q5T9C9	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	DEG_SPOP_SBC_1	22:26	AVTSS	SPOP	0.6064	More...
Q8N5C6	S1 RNA-binding domain-containing protein 1	DEG_SPOP_SBC_1	791:795	AVTSS	SPOP	0.801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons