DegronMD - Q8N5C6(SRBD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I787V	TCGA-AP-A1DK	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.E803K	TCGA-AX-A2HC	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1111
p.A929V	TCGA-AX-A2IN	UCEC	TCGA	FGIFVD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.25
p.S943C	TCGA-VS-A953	CESC	TCGA	FGIFVD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.1667
p.G933V	TCGA-Z2-AA3V	SKCM	TCGA	FGIFVD	LIG_APCC_ABBA_1	932:937	Mutation altering degron motif	0.6421
p.G933V	ACH-001061	Colon/Colorectal Cancer	CCLE	FGIFVD	LIG_APCC_ABBA_1	932:937	Mutation altering degron motif	0.6421
p.E153D	DO8730	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.2778
p.T154K	DO228971	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.D168E	DO229022	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0833
p.P165S	DO23240	LINC	ICGC	PSTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1667
p.S157N	DO37450	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.7069
p.V146I	DO51783	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0833
p.V146I	DO42312	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0833
p.P165L	DO41999	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1667
p.P947A	SIDM01157	Other Solid Cancers	GDSC	FGIFVD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.0556
p.P947A	ACH-001400	Cervical Cancer	CCLE	FGIFVD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.0556
p.P947A	SW954	vulva	COSMIC	FGIFVD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.0556
p.N802K	SIDM01608	Endometrial Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.N802K	ACH-000990	Endometrial/Uterine Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.N802Y	ACH-002357	Non-Cancerous	CCLE	AVTSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389

Kaplan plot for SRBD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRBD1

UniProt ID: Q8N5C6

Entrez ID: 55133

Protein name: S1 RNA-binding domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRBD1 in