DegronMD

Uniprot ID: Q8N5C6

Source protein: S1 RNA-binding domain-containing protein 1

Source gene: SRBD1

Class: LIG_APCC_ABBA_1

Location: 932:937

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5946

ASA_SCORE: 16.8333

COIL: 0.1717

CONS_SCORE: 0.832

DSS_SCORE: 0.0363

HELIX: 0.0085

FCONS_SCORE: 1.3223

RIG_SCORE: 0.9692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A929V	TCGA-AX-A2IN	UCEC	TCGA	FGIFVD	LIG_APCC_ABBA_1	0.25
p.S943C	TCGA-VS-A953	CESC	TCGA	FGIFVD	LIG_APCC_ABBA_1	0.1667
p.G933V	TCGA-Z2-AA3V	SKCM	TCGA	FGIFVD	LIG_APCC_ABBA_1	0.6421
p.G933V	ACH-001061	Colon/Colorectal Cancer	CCLE	FGIFVD	LIG_APCC_ABBA_1	0.6421
p.P947A	SIDM01157	Other Solid Cancers	GDSC	FGIFVD	LIG_APCC_ABBA_1	0.0556
p.P947A	ACH-001400	Cervical Cancer	CCLE	FGIFVD	LIG_APCC_ABBA_1	0.0556
p.P947A	SW954	vulva	COSMIC	FGIFVD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5C6	S1 RNA-binding domain-containing protein 1	LIG_APCC_ABBA_1	932:937	FGIFVD	APC,CDC20,FZR1	0.5946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons