DegronMD

Uniprot ID: Q8N5C6

Source protein: S1 RNA-binding domain-containing protein 1

Source gene: SRBD1

Class: DEG_SPOP_SBC_1

Location: 791:795

E3 ligase: SPOP

DEGRON score: 0.801

ASA_SCORE: 65.62

COIL: 0.6836

CONS_SCORE: 0.2085

DSS_SCORE: 0.3802

HELIX: 0.132

FCONS_SCORE: 0.9665

RIG_SCORE: 0.7661

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I787V	TCGA-AP-A1DK	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.2222
p.E803K	TCGA-AX-A2HC	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1111
p.N802K	SIDM01608	Endometrial Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.N802K	ACH-000990	Endometrial/Uterine Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	0.1389
p.N802Y	ACH-002357	Non-Cancerous	CCLE	AVTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	329:333	AVTSS	SPOP	0.9756	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	98:102	AVTSS	SPOP	0.9759	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	837:841	AVTSS	SPOP	0.9768	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	917:921	AVTSS	SPOP	0.9878	More...
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_SPOP_SBC_1	176:180	AVTSS	SPOP	0.9872	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	428:432	AVTSS	SPOP	0.9917	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	709:713	AVTSS	SPOP	0.6181	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	41:45	AVTSS	SPOP	0.9578	More...
Q5T9C9	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	DEG_SPOP_SBC_1	22:26	AVTSS	SPOP	0.6064	More...
Q8N5C6	S1 RNA-binding domain-containing protein 1	DEG_SPOP_SBC_1	791:795	AVTSS	SPOP	0.801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons