DegronMD

Uniprot ID: P57071

Source protein: PR domain zinc finger protein 15

Source gene: PRDM15

Class: DEG_SCF_FBW7_1

Location: 1357:1363

E3 ligase: FBXW7

DEGRON score: 0.6938

ASA_SCORE: 66.5571

COIL: 0.6097

CONS_SCORE: 0.6003

DSS_SCORE: 0.3776

HELIX: 0.0446

FCONS_SCORE: 0.8347

RIG_SCORE: 0.7244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1358N	TCGA-BT-A20N	BLCA	TCGA	VTTPSSS	DEG_SCF_FBW7_1	0.5944
p.P1373L	TCGA-D3-A8GM	SKCM	TCGA	VTTPSSS	DEG_SCF_FBW7_1	0.0556
p.S1362I	SIDM01039	Other Solid Cancers	GDSC	VTTPSSS	DEG_SCF_FBW7_1	0.623
p.S1362I	JAR	placenta	COSMIC	VTTPSSS	DEG_SCF_FBW7_1	0.623

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P57071	PR domain zinc finger protein 15	DEG_SCF_FBW7_1	1357:1363	VTTPSSS	FBXW7	0.6938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons