DegronMD

Uniprot ID: P57071

Source protein: PR domain zinc finger protein 15

Source gene: PRDM15

Class: DEG_SCF_FBW7_1

Location: 1454:1459

E3 ligase: FBXW7

DEGRON score: 0.9535

ASA_SCORE: 51.95

COIL: 0.7515

CONS_SCORE: 0.5973

DSS_SCORE: 0.3841

HELIX: 0.1197

FCONS_SCORE: 0.8896

RIG_SCORE: 0.7192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1449I	TCGA-AA-3864	COAD	TCGA	ITPLGS	DEG_SCF_FBW7_1	0.1944
p.T1455M	TCGA-BB-7870	HNSC	TCGA	ITPLGS	DEG_SCF_FBW7_1	0.7423
p.S1453Y	TCGA-DU-6392	LGG	TCGA	ITPLGS	DEG_SCF_FBW7_1	0.3056
p.F1444L	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	ITPLGS	DEG_SCF_FBW7_1	0.0556
p.F1444L	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	ITPLGS	DEG_SCF_FBW7_1	0.0556
p.T1468M	ACH-000999	Colon/Colorectal Cancer	CCLE	ITPLGS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P57071	PR domain zinc finger protein 15	DEG_SCF_FBW7_1	1454:1459	ITPLGS	FBXW7	0.9535	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons