DegronMD

Uniprot ID: Q8IWZ3

Source protein: Ankyrin repeat and KH domain-containing protein 1

Source gene: ANKHD1

Class: DEG_SCF_FBW7_1

Location: 1779:1785

E3 ligase: FBXW7

DEGRON score: 0.9961

ASA_SCORE: 96.8143

COIL: 0.9199

CONS_SCORE: 0.3712

DSS_SCORE: 0.4539

HELIX: 0.0361

FCONS_SCORE: 0.9035

RIG_SCORE: 0.705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1789N	TCGA-AA-3984	COAD	TCGA	IRTPAST	DEG_SCF_FBW7_1	0.2222
p.E1771D	TCGA-EO-A22U	UCEC	TCGA	IRTPAST	DEG_SCF_FBW7_1	0.1111
p.H1789Y	DO45151	LIRI	ICGC	IRTPAST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SCF_FBW7_1	1779:1785	IRTPAST	FBXW7	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons