DegronMD

Uniprot ID: Q8IWZ3

Source protein: Ankyrin repeat and KH domain-containing protein 1

Source gene: ANKHD1

Class: LIG_APCC_ABBA_1

Location: 44:49

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6414

ASA_SCORE: 42.0333

COIL: 0.18

CONS_SCORE: 0.4161

DSS_SCORE: 0.4845

HELIX: 0.5277

FCONS_SCORE: 1.1776

RIG_SCORE: 0.7896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L46R	TCGA-19-0957	GBM	TCGA	VRLFGE	LIG_APCC_ABBA_1	0.8428
p.L46R	DO11028	GBM	ICGC	VRLFGE	LIG_APCC_ABBA_1	0.8428
p.V35M	DO44525	KIRP	ICGC	VRLFGE	LIG_APCC_ABBA_1	0.0833
p.L39V	DO231672	LINC	ICGC	VRLFGE	LIG_APCC_ABBA_1	0.1944
p.P34L	DO26280	LUAD	ICGC	VRLFGE	LIG_APCC_ABBA_1	0.0556
p.P54Q	DO37782	SKCM	ICGC	VRLFGE	LIG_APCC_ABBA_1	0.6389
p.L49F	DO41331	UCEC	ICGC	VRLFGE	LIG_APCC_ABBA_1	0.6981
p.S48P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VRLFGE	LIG_APCC_ABBA_1	0.6752
p.S43N	KP-1N	pancreas	COSMIC	VRLFGE	LIG_APCC_ABBA_1	0.75
p.I56K	NCI-H1734	lung	COSMIC	VRLFGE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	LIG_APCC_ABBA_1	44:49	VRLFGE	APC,CDC20,FZR1	0.6414	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons