DegronMD

Uniprot ID: Q9P206

Source protein: Uncharacterized protein KIAA1522

Source gene: KIAA1522

Class: DEG_SPOP_SBC_1

Location: 637:641

E3 ligase: SPOP

DEGRON score: 0.942

ASA_SCORE: 93.12

COIL: 0.958

CONS_SCORE: 0.4813

DSS_SCORE: 0.6935

HELIX: 0.0174

FCONS_SCORE: 0.9928

RIG_SCORE: 0.5748

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S628F	TCGA-52-7810	LUSC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0833
p.G647W	TCGA-D3-A2JC	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.R645C	TCGA-DU-7010	LGG	TCGA	PVSTT	DEG_SPOP_SBC_1	0.2222
p.S639F	DO51906	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7982
p.Q646K	DO51903	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.A630T	DO229016	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.A630T	DO229003	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.A630T	DO229480	LAML	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.A643T	DO13863	GBM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.V638F	DO229018	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.5957
p.R645H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PVSTT	DEG_SPOP_SBC_1	0.2222
p.R645H	SIDM00282	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.2222
p.R645H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.2222
p.R645H	CW-2	large_intestine	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.2222
p.D644N	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.25
p.D644N	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.25
p.S647F	ACH-000607	Rhabdoid	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1667
p.S647F	KYM-1	soft_tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with KIAA1522 mutations

All proteins holding degron of PVSTT