DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 1755:1759

E3 ligase: SPOP

DEGRON score: 0.7406

ASA_SCORE: 87.84

COIL: 0.869

CONS_SCORE: 0.5499

DSS_SCORE: 0.6111

HELIX: 0.012

FCONS_SCORE: 0.933

RIG_SCORE: 0.7178

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1759M	TCGA-17-Z055	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T1759M	TCGA-HT-7687	LGG	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T1759M	DO22151	LGG	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.G1747E	TCGA-EE-A3AG	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G1747E	DO37471	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.E1765D	TCGA-HT-8106	LGG	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E1765D	DO22711	LGG	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E1765K	TCGA-PJ-A8JU	KIRP	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E1765K	DO48523	KIRP	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.T1748I	DO225007	BRCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.S1757G	DO50452	ESAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.6993
p.I1754M	DO228950	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.I1754M	DO229030	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.T1748S	DO228960	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T1749P	DO228584	MALY	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.S1753R	SIDM01126	Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S1753R	ACH-001599	Lung Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S1753R	NCI-H64	lung	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S1767N	SIDM00963	Breast Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S1767I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S1767I	ACH-000672	Lung Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S1767I	IA-LM	lung	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT