DegronMD

Uniprot ID: Q6ZSZ6

Source protein: Teashirt homolog 1

Source gene: TSHZ1

Class: DEG_SPOP_SBC_1

Location: 164:168

E3 ligase: SPOP

DEGRON score: 0.8971

ASA_SCORE: 93.8

COIL: 0.9476

CONS_SCORE: 0.2876

DSS_SCORE: 0.6551

HELIX: 0.0202

FCONS_SCORE: 0.8997

RIG_SCORE: 0.6025

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H155N	DO8730	COAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.T159P	DO223098	ESCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.T159P	DO229208	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.T159P	DO229211	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.T159P	DO229250	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.S176N	DO233277	GACA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S154F	DO233702	GACA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.S154F	SIDM00007	Other Solid Cancers	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.T162P	DO229191	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.T162P	DO229204	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.T162P	DO229232	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.P156T	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.P156T	SIDM01169	Ovarian Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.P156T	SIDM00504	Glioma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.P156T	SIDM00197	Ewing's Sarcoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.P156T	SIDM00507	Other Solid Cancers	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.P156T	SIDM00142	Endometrial Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.P156T	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.P156T	SIDM01592	Breast Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.T168I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7078
p.T168I	SIDM00537	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7078
p.T157I	SIDM00828	Other Sarcomas	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T166M	TGBC11TKB	stomach	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with TSHZ1 mutations

All proteins holding degron of PVSTT