DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 1402:1406

E3 ligase: SPOP

DEGRON score: 0.678

ASA_SCORE: 90.5

COIL: 0.9226

CONS_SCORE: 0.5236

DSS_SCORE: 0.6

HELIX: 0.0096

FCONS_SCORE: 1

RIG_SCORE: 0.6999

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1397L	TCGA-06-2557	GBM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	TCGA-44-7662	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	TCGA-BR-6852	STAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	TCGA-DB-A64L	LGG	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	TCGA-EO-A22R	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	DO13318	GBM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	DO44615	LGG	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	DO23597	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	DO38202	STAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	DO42713	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	SIDM01146	Gastric Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	SIDM01554	Mesothelioma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1397L	NCI-SNU-1	stomach	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.T1405S	TCGA-3C-AALI	BRCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.6005
p.T1405S	DO219589	BRCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.6005
p.T1406M	TCGA-93-A4JN	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T1406M	DO218931	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T1406M	DO27833	MALY	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.S1414T	TCGA-95-7043	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S1414T	DO24739	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.E1393K	TCGA-DA-A95Z	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E1393K	TCGA-FR-A8YE	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E1393K	DO229459	SKCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E1393K	DO50303	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E1393K	DO219481	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.G1394E	TCGA-EE-A181	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G1394E	TCGA-W3-A825	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G1394E	DO37444	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G1394E	DO51272	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.E1393D	DO228299	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.T1395S	DO229057	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T1395S	SIDM01180	Hepatocellular Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T1395S	SNU-387	liver	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.V1403D	SIDM00884	Breast Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.6674
p.V1403D	SIDM01180	Hepatocellular Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.6674
p.V1403D	SIDM01318	Hepatocellular Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.6674
p.V1403D	SIDM01624	Bladder Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.6674
p.V1403D	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PVSTT	DEG_SPOP_SBC_1	0.6674
p.V1403D	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.6674
p.V1403D	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.6674
p.V1403D	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.6674
p.I1401M	SIDM01180	Hepatocellular Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.I1401M	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.I1401M	SNU-387	liver	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...