DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 2344:2348

E3 ligase: SPOP

DEGRON score: 0.9456

ASA_SCORE: 85.52

COIL: 0.8018

CONS_SCORE: 0.7504

DSS_SCORE: 0.5863

HELIX: 0.0196

FCONS_SCORE: 1.1427

RIG_SCORE: 0.7496

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2342C	TCGA-AA-3864	COAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.2778
p.R2342C	TCGA-G4-6588	COAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.2778
p.R2342C	DO10140	COAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.R2342C	DO8490	COAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.P2339S	TCGA-AP-A1DV	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2339S	DO43186	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.M2349T	TCGA-DD-AACF	LIHC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.3056
p.M2349T	DO52201	LIHC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.P2339L	TCGA-EE-A3J5	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2339L	DO222644	MELA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2339L	DO47331	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.T2347I	TCGA-MN-A4N4	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7078
p.T2347I	DO26250	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7078
p.G2336E	TCGA-YD-A9TA	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G2336E	DO219503	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S2346N	DO48371	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7069
p.R2342S	DO229030	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S2352C	DO48715	LIRI	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2222
p.T2355K	DO230968	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355K	DO224621	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM01652	Non-Cancerous	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM00266	Ewing's Sarcoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM01161	Other Sarcomas	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM00899	Pancreatic Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM00223	Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM00853	Other Sarcomas	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM00836	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM00063	Melanoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM01107	Melanoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM01193	Glioma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM01757	Bladder Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2355I	SIDM01566	Hodgkin's Lymphoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.P2344T	SIDM01318	Hepatocellular Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7031
p.P2344T	ACH-001318	Liver Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.7031
p.V2350G	SIDM00500	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.V2350G	ACH-000959	Colon/Colorectal Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...