DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 2167:2171

E3 ligase: SPOP

DEGRON score: 0.6746

ASA_SCORE: 87.42

COIL: 0.8622

CONS_SCORE: 0.5236

DSS_SCORE: 0.4889

HELIX: 0.0176

FCONS_SCORE: 1

RIG_SCORE: 0.7553

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2167A	TCGA-17-Z000	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.6392
p.A2174V	TCGA-2W-A8YY	CESC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.25
p.A2174V	DO223732	CESC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.V2173G	TCGA-AP-A051	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.2778
p.V2173G	DO42673	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S2165C	TCGA-AZ-4681	COAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S2165C	DO9306	COAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.T2161I	TCGA-B5-A3FC	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.T2161I	DO41871	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.S2176C	TCGA-C8-A12T	BRCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.S2176C	DO5507	BRCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.S2165N	TCGA-DU-6392	LGG	TCGA	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S2165N	DO22237	LGG	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.L2181F	TCGA-EO-A22U	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0556
p.L2181F	DO43755	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.L2181F	SIDM00797	Melanoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.L2181F	ACH-000788	Skin Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.0556
p.L2181F	A2058	skin	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.M2166T	TCGA-EO-A22X	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.3056
p.M2166T	DO43907	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R2160K	TCGA-OL-A66P	BRCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1389
p.R2160K	DO44182	BRCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.R2160I	TCGA-QF-A5YS	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1389
p.R2160I	DO52426	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.V2172L	DO224731	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.V2172L	DO228926	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.V2172L	DO228941	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.V2172L	DO228947	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.V2172L	DO228974	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R2159G	DO229013	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2159G	DO229016	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2159G	DO228941	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2159G	DO228947	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2160S	DO228960	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.R2160S	DO229030	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.S2169I	DO229034	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7341
p.V2173L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.V2173L	ACH-001363	Lung Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.2778
p.V2173L	NCI-H2135	lung	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.T2164I	SIDM01372	Pancreatic Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.25
p.T2164I	ACH-000266	Pancreatic Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.25
p.T2180I	SIDM01613	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...