DegronMD - Q96RL7(VPS13A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y2487C	TCGA-66-2744	LUSC	TCGA	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation rewiring degron network	0.0556
p.Y2487C	DO27025	LUSC	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation rewiring degron network	0.0556
p.P1015L	TCGA-B5-A11E	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation rewiring degron network	0.1111
p.P1015L	DO41644	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation rewiring degron network	0.1111
p.S1409G	TCGA-B5-A1MW	UCEC	TCGA	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.8104
p.S1409G	DO42913	UCEC	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.8104
p.M1405I	TCGA-BF-A1PZ	SKCM	TCGA	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.6507
p.M1405I	DO50279	SKCM	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.6507
p.R2497C	TCGA-BF-AAP1	SKCM	TCGA	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation altering degron motif	0.8301
p.R2497C	DO230342	COCA	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation altering degron motif	0.8301
p.R2497C	DO219464	SKCM	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation altering degron motif	0.8301
p.R2497C	SIDM00983	Bladder Carcinoma	GDSC	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation altering degron motif	0.8301
p.R2497C	ACH-000896	Bladder Cancer	CCLE	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation altering degron motif	0.8301
p.R2497C	647-V	urinary tract	COSMIC	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation altering degron motif	0.8301
p.R2234Q	TCGA-BR-4370	STAD	TCGA	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.25
p.R2234Q	TCGA-BS-A0UV	UCEC	TCGA	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.25
p.R2234Q	TCGA-QS-A5YQ	UCEC	TCGA	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.25
p.R2234Q	DO38499	STAD	ICGC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.25
p.R2234Q	DO49073	UCEC	ICGC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.25
p.R2234Q	DO42793	UCEC	ICGC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.25
p.R2624I	TCGA-CA-6717	COAD	TCGA	RRNYLPALK	DEG_APCC_DBOX_1	2623:2631	Mutation altering degron motif	0.8102
p.R2624I	DO8264	COAD	ICGC	RRNYLPALK	DEG_APCC_DBOX_1	2623:2631	Mutation altering degron motif	0.8102
p.S1416F	TCGA-DA-A95Z	SKCM	TCGA	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation blocking phosphorylation signal	0.6667
p.S1416F	DO219481	SKCM	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation blocking phosphorylation signal	0.6667
p.R2623Q	TCGA-DF-A2KV	UCEC	TCGA	RRNYLPALK	DEG_APCC_DBOX_1	2623:2631	Mutation altering degron motif	0.6218
p.R2623Q	DO219771	UCEC	ICGC	RRNYLPALK	DEG_APCC_DBOX_1	2623:2631	Mutation altering degron motif	0.6218
p.S1409N	TCGA-EK-A2R8	CESC	TCGA	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.818
p.S1409N	DO51599	CESC	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.818
p.P1410Q	TCGA-ER-A19P	SKCM	TCGA	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.5924
p.P1410Q	DO47623	SKCM	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.5924
p.K1037E	TCGA-F1-6874	STAD	TCGA	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation substituting flanking lysine	0.1667
p.K1037E	DO38201	STAD	ICGC	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation substituting flanking lysine	0.1667
p.V2632G	TCGA-IC-A6RF	ESCA	TCGA	RRNYLPALK	DEG_APCC_DBOX_1	2623:2631	Mutation rewiring degron network	0.3056
p.P2238S	TCGA-VQ-A8P2	STAD	TCGA	PPNY	ITCH	2237:2240	Mutation altering degron motif	0.6752
p.P2238S	DO51761	STAD	ICGC	PPNY	ITCH	2237:2240	Mutation altering degron motif	0.6752
p.Y1408C	DO218269	BRCA	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.7087
p.R2497H	DO222864	COCA	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation altering degron motif	0.8244
p.R2497H	DO222354	LICA	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation altering degron motif	0.8244
p.G1411V	DO48225	ESCA	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.6421
p.Y1408H	DO233867	GACA	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.7229
p.Y1408H	DO221541	PACA	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.7229
p.D2230G	DO228239	LICA	ICGC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1389
p.S1409I	DO228974	LICA	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.8453
p.S1409I	SIDM00660	Colorectal Carcinoma	GDSC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.8453
p.S1409I	ACH-000985	Colon/Colorectal Cancer	CCLE	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.8453
p.S1409I	LS-411N	large intestine	COSMIC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.8453
p.R2497L	DO229015	LICA	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation altering degron motif	0.8428
p.R1421L	DO229031	LICA	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation rewiring degron network	0.0833
p.S2637F	DO229050	LICA	ICGC	RRNYLPALK	DEG_APCC_DBOX_1	2623:2631	Mutation rewiring degron network	0.1667
p.A2638E	DO229050	LICA	ICGC	RRNYLPALK	DEG_APCC_DBOX_1	2623:2631	Mutation rewiring degron network	0.1389
p.R2234L	DO23304	LINC	ICGC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.25
p.S1409T	DO230541	LUSC	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.7116
p.R1421C	DO27809	MALY	ICGC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation rewiring degron network	0.0833
p.N2625K	DO228504	MALY	ICGC	RRNYLPALK	DEG_APCC_DBOX_1	2623:2631	Mutation altering degron motif	0.5806
p.E1030K	DO222908	MELA	ICGC	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation rewiring degron network	0.25
p.R2506S	DO35083	PACA	ICGC	IILFTE	LIG_APCC_ABBA_1	2498:2503	Mutation rewiring degron network	0.25
p.R2506S	DO35083	PACA	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	2497:2503	Mutation rewiring degron network	0.25
p.S1021L	DO219878	SKCA	ICGC	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation rewiring degron network	0.2778
p.P2237S	DO229213	THCA	ICGC	PPNY	ITCH	2237:2240	Mutation altering degron motif	0.6752
p.P2243T	DO229242	THCA	ICGC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.25
p.I1036V	DO229242	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation rewiring degron network	0.0833
p.E1028G	SIDM00128	Head and Neck Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation rewiring degron network	0.3056
p.E1028G	SIDM00481	Ovarian Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation rewiring degron network	0.3056
p.E1028G	SIDM00520	Mesothelioma	GDSC	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation rewiring degron network	0.3056
p.E1028G	SIDM00335	Endometrial Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation rewiring degron network	0.3056
p.E1028G	SIDM01750	Melanoma	GDSC	PVSTT	DEG_SPOP_SBC_1	1023:1027	Mutation rewiring degron network	0.3056
p.S2247Y	SIDM01206	Neuroblastoma	GDSC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1389
p.S2247Y	ACH-002248	Neuroblastoma	CCLE	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1389
p.S2247Y	IMR-5	autonomic ganglia	COSMIC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1389
p.G2231R	SIDM01165	Pancreatic Carcinoma	GDSC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1667
p.G2231R	ACH-000155	Pancreatic Cancer	CCLE	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1667
p.G2231R	SW1990	pancreas	COSMIC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1667
p.S2247T	SIDM00543	Melanoma	GDSC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1389
p.S2247T	SIDM01372	Pancreatic Carcinoma	GDSC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1389
p.S2247T	ACH-000266	Pancreatic Cancer	CCLE	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1389
p.S2247T	ACH-002120	Skin Cancer	CCLE	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1389
p.S2247T	GAK	skin	COSMIC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1389
p.F2246Y	SIDM01511	Gastric Carcinoma	GDSC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1667
p.F2246Y	ACH-000746	Gastric Cancer	CCLE	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.1667
p.V2621E	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RRNYLPALK	DEG_APCC_DBOX_1	2623:2631	Mutation rewiring degron network	0.2778
p.D2236H	NCI-H2009	lung	COSMIC	PPNY	ITCH	2237:2240	Mutation rewiring degron network	0.3056
p.G1406S	DMS-273	lung	COSMIC	DLTMVLYSPGP	CBL_PTK	1402:1412	Mutation altering degron motif	0.6993

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VPS13A

UniProt ID: Q96RL7

Entrez ID: 23230

Protein name: Intermembrane lipid transfer protein VPS13A (Chorea-acanthocytosis protein) (Chorein) (Vacuolar protein sorting-associated protein 13A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VPS13A in