DegronMD

Uniprot ID: Q96RL7

Source protein: Intermembrane lipid transfer protein VPS13A

Source gene: VPS13A

Class: DEG_APCC_DBOX_1

Location: 2623:2631

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5002

ASA_SCORE: 57.8222

COIL: 0.4157

CONS_SCORE: 0.3868

DSS_SCORE: 0.1131

HELIX: 0.1019

FCONS_SCORE: 1.2907

RIG_SCORE: 0.8463

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2624I	TCGA-CA-6717	COAD	TCGA	RRNYLPALK	DEG_APCC_DBOX_1	0.8102
p.R2624I	DO8264	COAD	ICGC	RRNYLPALK	DEG_APCC_DBOX_1	0.8102
p.R2623Q	TCGA-DF-A2KV	UCEC	TCGA	RRNYLPALK	DEG_APCC_DBOX_1	0.6218
p.R2623Q	DO219771	UCEC	ICGC	RRNYLPALK	DEG_APCC_DBOX_1	0.6218
p.N2625K	DO228504	MALY	ICGC	RRNYLPALK	DEG_APCC_DBOX_1	0.5806
p.V2632G	TCGA-IC-A6RF	ESCA	TCGA	RRNYLPALK	DEG_APCC_DBOX_1	0.3056
p.V2621E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RRNYLPALK	DEG_APCC_DBOX_1	0.2778
p.S2637F	DO229050	LICA	ICGC	RRNYLPALK	DEG_APCC_DBOX_1	0.1667
p.A2638E	DO229050	LICA	ICGC	RRNYLPALK	DEG_APCC_DBOX_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_APCC_DBOX_1	2623:2631	RRNYLPALK	APC,CDC20,FZR1	0.5002	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons