DegronMD

Uniprot ID: Q96RL7

Source protein: Intermembrane lipid transfer protein VPS13A

Source gene: VPS13A

Class: DEG_SPOP_SBC_1

Location: 1023:1027

E3 ligase: SPOP

DEGRON score: 0.8888

ASA_SCORE: 83.98

COIL: 0.9316

CONS_SCORE: 0.206

DSS_SCORE: 0.609

HELIX: 0.0344

FCONS_SCORE: 0.8873

RIG_SCORE: 0.6656

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1015L	TCGA-B5-A11E	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.P1015L	DO41644	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.K1037E	TCGA-F1-6874	STAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.K1037E	DO38201	STAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E1030K	DO222908	MELA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.S1021L	DO219878	SKCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.I1036V	DO229242	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E1028G	SIDM00128	Head and Neck Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.E1028G	SIDM00481	Ovarian Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.E1028G	SIDM00520	Mesothelioma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.E1028G	SIDM00335	Endometrial Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.E1028G	SIDM01750	Melanoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with VPS13A mutations

All proteins holding degron of PVSTT