DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 1284:1288

E3 ligase: SPOP

DEGRON score: 0.7705

ASA_SCORE: 94.18

COIL: 0.912

CONS_SCORE: 0.5236

DSS_SCORE: 0.484

HELIX: 0.0128

FCONS_SCORE: 1

RIG_SCORE: 0.7823

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1283M	TCGA-17-Z000	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.3056
p.S1274T	TCGA-AA-3697	COAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0556
p.S1274T	DO8424	COAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.S1274T	SIDM00831	Head and Neck Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.S1274T	ACH-000207	Head and Neck Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.0556
p.S1274T	Detroit562	upper_aerodigestive_tract	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.L1279I	TCGA-AG-A002	READ	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.E1294K	TCGA-CR-5248	HNSC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E1294K	DO14694	HNSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.P1284L	TCGA-EE-A2GJ	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7582
p.P1284L	DO37746	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7582
p.G1276E	TCGA-FS-A4F8	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G1276E	DO38117	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.T1291S	DO224708	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.T1291S	DO224812	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.T1291S	DO222553	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.T1291S	DO229013	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.T1291S	DO229016	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.T1291S	DO51009	LAML	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.T1291S	DO52361	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.T1291S	DO52359	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.T1288K	DO222553	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7306
p.T1288K	DO222835	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7306
p.T1288K	DO229013	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7306
p.T1288K	DO229016	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7306
p.T1288K	DO51020	LAML	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7306
p.T1288K	DO51011	LAML	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7306
p.T1288K	DO51009	LAML	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7306
p.T1288K	DO52359	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7306
p.T1288K	DO218859	SKCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7306
p.S1277I	DO222553	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.S1277I	DO229013	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.S1277I	DO229016	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.S1277I	DO52365	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.E1294Q	DO231132	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E1275K	DO229456	SKCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.P1284H	SIDM01078	Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7694
p.P1284H	ACH-000790	Lung Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.7694
p.P1284H	SHP-77	lung	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.7694
p.T1297N	SIDM01110	Hepatocellular Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.T1297N	ACH-000361	Liver Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.0833
p.T1297N	SK-HEP-1	liver	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.S1282C	SIDM00653	Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S1282C	NCI-H1092	lung	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.G1276R	ACH-002061	Leukemia	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...