DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 2462:2466

E3 ligase: SPOP

DEGRON score: 0.5519

ASA_SCORE: 87.02

COIL: 0.8476

CONS_SCORE: 0.5236

DSS_SCORE: 0.6331

HELIX: 0.011

FCONS_SCORE: 1

RIG_SCORE: 0.6749

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2457L	TCGA-59-2349	OV	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2457L	DO220889	MELA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2457L	DO28621	OV	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2457T	TCGA-67-3770	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2457T	DO23932	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.L2458I	TCGA-67-6217	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.2222
p.L2458I	DO25877	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2222
p.P2467L	TCGA-AA-3715	COAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.3056
p.P2467L	DO8018	COAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.V2463F	TCGA-AP-A054	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.5957
p.V2463F	DO42256	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.5957
p.T2456N	TCGA-DX-A3U5	SARC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.T2456N	DO219972	SARC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.T2475I	TCGA-EE-A2MR	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0833
p.T2475I	DO37819	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2453K	TCGA-ER-A19A	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2453K	TCGA-ER-A19K	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2453K	DO222702	MELA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2453K	DO218850	SKCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2453K	DO47425	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2453K	DO47672	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2472G	TCGA-GN-A266	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E2472G	DO37432	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.P2457A	TCGA-LT-A5Z6	BLCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2457A	DO44029	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.A2459T	DO224775	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.A2459T	DO228611	GACA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.G2474S	DO224716	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G2474S	DO228915	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G2474S	DO229053	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.A2473S	DO228615	GACA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.V2469A	DO228934	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.V2469A	DO228937	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.V2469A	DO229030	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.S2471P	DO228937	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.T2455S	DO228950	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2455S	DO229030	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T2455I	DO218863	SKCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.E2472D	SIDM01156	Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E2472D	ACH-000890	Lung Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E2472D	SW1271	lung	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.P2457Q	SIDM00690	Head and Neck Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2457Q	ACH-002251	Head and Neck Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2457Q	JHU-029	upper_aerodigestive_tract	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.M2461I	MDA-MB-361	breast	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...