DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3052:3056

E3 ligase: SPOP

DEGRON score: 0.791

ASA_SCORE: 86.46

COIL: 0.8512

CONS_SCORE: 0.6368

DSS_SCORE: 0.556

HELIX: 0.011

FCONS_SCORE: 1.0299

RIG_SCORE: 0.7268

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3054G	TCGA-17-Z001	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.6993
p.P3061L	TCGA-17-Z020	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P3061S	TCGA-24-1845	OV	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P3061S	DO29920	OV	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.S3045C	TCGA-BH-A0E0	BRCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1389
p.S3045C	DO1384	BRCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.P3047S	TCGA-DU-6407	LGG	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P3047S	DO22295	LGG	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.A3059G	TCGA-E7-A4IJ	BLCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.25
p.A3059G	DO453	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.E3043D	TCGA-MI-A75I	LIHC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E3043D	DO49712	LIHC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.P3057L	TCGA-UY-A9PB	BLCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.3056
p.P3057L	DO219041	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.P3047L	TCGA-YD-A9TA	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P3047L	DO219503	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.T3056M	DO222530	BTCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T3056M	DO229016	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T3056M	DO230659	LAML	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T3056M	DO231140	LAML	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T3056M	DO228941	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T3056M	DO228947	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T3056M	DO229047	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.S3064R	DO228264	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S3045T	DO229052	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.I3051M	DO229052	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.I3051M	ACH-002272	Lymphoma	CCLE	PVSTT	DEG_SPOP_SBC_1	0.3056
p.I3051M	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.I3060S	DO229057	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2222
p.P3052S	SIDM00608	Plasma Cell Myeloma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.6752
p.P3052S	ACH-000714	Myeloma	CCLE	PVSTT	DEG_SPOP_SBC_1	0.6752
p.P3052S	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.6752
p.T3055A	SIDM01638	Non-Cancerous	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7139
p.T3055A	SIDM00172	Head and Neck Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7139
p.T3055A	ACH-002212	Head and Neck Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.7139
p.T3055A	ACH-002342	Non-Cancerous	CCLE	PVSTT	DEG_SPOP_SBC_1	0.7139
p.P3052H	ACH-001623	Brain Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.7694

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...