DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 2050:2054

E3 ligase: SPOP

DEGRON score: 0.8263

ASA_SCORE: 87.68

COIL: 0.7892

CONS_SCORE: 0.5236

DSS_SCORE: 0.5987

HELIX: 0.017

FCONS_SCORE: 1

RIG_SCORE: 0.755

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2042W	TCGA-06-5418	GBM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2042W	DO12274	GBM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2042W	SIDM00789	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2042W	ACH-000997	Colon/Colorectal Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2042W	ACH-001061	Colon/Colorectal Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2042W	HCT-15	large_intestine	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.E2041K	TCGA-BP-5173	KIRC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2041K	TCGA-FW-A3R5	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2041K	DO20289	KIRC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2041K	DO37406	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.R2042Q	TCGA-BR-7707	STAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2042Q	DO38487	STAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2042Q	SIDM01665	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R2042Q	ACH-000089	Colon/Colorectal Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1111
p.T2054M	TCGA-BR-8078	STAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T2054M	DO38288	STAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.N2062T	TCGA-BR-8589	STAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.N2062T	DO47813	STAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.P2045S	TCGA-EE-A2MR	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P2045S	DO37819	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.E2060K	DO231207	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.P2050H	SIDM00291	Melanoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7694
p.P2050H	ACH-002040	Skin Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.7694
p.P2050H	HMV-II	skin	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.7694
p.G2048R	SIDM01071	Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.G2048D	ACH-000160	Rhabdoid	CCLE	PVSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT