DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 1932:1936

E3 ligase: SPOP

DEGRON score: 0.9647

ASA_SCORE: 86.02

COIL: 0.8298

CONS_SCORE: 0.5236

DSS_SCORE: 0.6032

HELIX: 0.0138

FCONS_SCORE: 0.9593

RIG_SCORE: 0.7196

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1935S	TCGA-05-4410	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.6005
p.T1935S	DO25426	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.6005
p.P1932L	TCGA-24-1927	OV	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7582
p.P1932L	DO31604	OV	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7582
p.T1945N	TCGA-64-5774	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.5278
p.T1945N	DO24770	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.5278
p.T1945A	TCGA-F5-6814	READ	TCGA	PVSTT	DEG_SPOP_SBC_1	0.5278
p.T1945A	DO36556	READ	ICGC	PVSTT	DEG_SPOP_SBC_1	0.5278
p.L1946F	TCGA-FR-A729	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0556
p.L1946F	DO48618	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.L1946F	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.L1946F	ACH-000757	Lung Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.0556
p.L1946F	A427	lung	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.P1926L	TCGA-W3-A825	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.P1926L	DO51272	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.I1943T	DO224731	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.I1931M	DO224731	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.I1931M	DO48940	PBCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.T1945S	DO224731	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.5278
p.R1922S	DO228828	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.R1922S	DO228291	MALY	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.E1942K	DO231075	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.G1924E	DO218912	SKCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.R1925M	SIDM00216	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.R1925M	ACH-000989	Colon/Colorectal Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1389
p.R1925M	SNU-175	large_intestine	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.R1922G	SIDM00919	Ovarian Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.R1922G	ACH-000713	Ovarian Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.0556
p.R1922G	Caov-3	ovary	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.S1930R	ACH-001796	Liposarcoma	CCLE	PVSTT	DEG_SPOP_SBC_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...