DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 1166:1170

E3 ligase: SPOP

DEGRON score: 0.615

ASA_SCORE: 85.38

COIL: 0.7512

CONS_SCORE: 0.5236

DSS_SCORE: 0.5488

HELIX: 0.015

FCONS_SCORE: 1

RIG_SCORE: 0.7448

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1166H	TCGA-A5-A0G2	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7694
p.P1166H	DO41235	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7694
p.P1161L	TCGA-B5-A3FA	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1161L	TCGA-EO-A22T	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1161L	TCGA-W3-AA1R	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1161L	DO51275	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1161L	DO42320	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1161L	DO52402	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.E1176K	TCGA-BT-A42F	BLCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E1176K	DO49726	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.P1161S	TCGA-EE-A2MG	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P1161S	DO37421	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.V1172L	TCGA-QG-A5Z1	COAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.2778
p.V1172L	DO51731	COAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.G1158E	TCGA-W3-A825	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G1158E	DO51272	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.P1161Q	DO222884	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.T1159I	DO230659	LAML	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T1159I	DO231140	LAML	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T1159I	DO228941	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.T1159I	DO228947	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.L1171P	DO228967	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.V1173A	DO229030	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.V1173A	DO228349	MALY	ICGC	PVSTT	DEG_SPOP_SBC_1	0.25
p.V1173A	ACH-000091	Ovarian Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.25
p.V1173A	OV-56	ovary	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.25
p.N1178S	DO229057	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.N1178S	DO229060	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.N1178S	DO228375	MALY	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S1156N	SIDM01314	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.T1170M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T1170M	SIDM00982	Glioblastoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T1170M	SIDM00901	Endometrial Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.S1174N	SIDM00190	Melanoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.2222
p.S1174N	ACH-002097	Skin Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.2222
p.S1174N	CP66-MEL	skin	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.2222
p.T1179I	SIDM00260	Gastric Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.T1179I	SIDM00248	Gastric Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.T1179I	ACH-000758	Gastric Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.0833
p.T1179I	ACH-002161	Gastric Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.0833
p.T1179I	MKN28	stomach	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.S1168R	SIDM00965	Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.7427
p.S1168R	ACH-000800	Lung Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.7427
p.S1168R	NCI-H446	lung	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.7427
p.M1165V	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...