DegronMD - O15034(RIMBP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A698V	TCGA-59-2349	OV	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A698V	TCGA-AA-3966	COAD	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A698V	DO10068	COAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A698V	DO230524	LUSC	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A698V	DO28621	OV	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A698V	SIDM00217	Colorectal Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A698V	ACH-000999	Colon/Colorectal Cancer	CCLE	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A698V	SNU-1040	large intestine	COSMIC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A703S	TCGA-85-7843	LUSC	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.0833
p.A703S	DO26500	LUSC	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.0833
p.A698T	TCGA-BR-8371	STAD	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A698T	TCGA-DB-A64S	LGG	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A698T	DO44619	LGG	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.A698T	DO47950	STAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222
p.S690G	TCGA-BS-A0TJ	UCEC	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.6993
p.S690G	DO42953	UCEC	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.6993
p.E694D	TCGA-DA-A3F5	SKCM	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5647
p.E694D	DO37435	SKCM	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5647
p.G699R	TCGA-DI-A1BU	UCEC	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.1944
p.G699R	DO42023	UCEC	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.1944
p.R674W	TCGA-EY-A1GU	UCEC	TCGA	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.1111
p.R674W	TCGA-EY-A1GU	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.R674W	DO41518	UCEC	ICGC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.1111
p.R674W	DO41518	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.P659Q	TCGA-FS-A1ZJ	SKCM	TCGA	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation altering degron motif	0.7035
p.P659Q	DO37956	SKCM	ICGC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation altering degron motif	0.7035
p.E687D	TCGA-G4-6323	COAD	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.3056
p.E687D	DO9138	COAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.3056
p.L656M	TCGA-UZ-A9PS	KIRP	TCGA	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.25
p.L656M	TCGA-UZ-A9PS	KIRP	TCGA	PVSTT	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.L656M	DO219709	KIRP	ICGC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.25
p.L656M	DO219709	KIRP	ICGC	PVSTT	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.R689K	DO48389	BLCA	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.6126
p.A702T	DO234219	ESAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.1111
p.Q700R	DO233734	GACA	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.1667
p.Q658K	DO228974	LICA	ICGC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.3056
p.Q658K	DO228974	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1944
p.S649L	DO224745	PACA	ICGC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.0556
p.S683C	DO51962	PRAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.1944
p.E675V	DO229259	THCA	ICGC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.0833
p.E675V	DO229259	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1111
p.A677S	DO229272	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.0556
p.Q678H	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.0556
p.V691L	SIDM00231	Kidney Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5654
p.V691L	NCC010	kidney	COSMIC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5654
p.V691I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5965
p.V691I	SIDM01147	Gastric Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5965
p.L656Q	SIDM00537	Colorectal Carcinoma	GDSC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.25
p.L656Q	SIDM00537	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.L656Q	ACH-000982	Colon/Colorectal Cancer	CCLE	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.25
p.L656Q	ACH-000982	Colon/Colorectal Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.L656Q	ACH-001345	Colon/Colorectal Cancer	CCLE	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.25
p.L656Q	ACH-001345	Colon/Colorectal Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.G699W	SIDM01387	Small Cell Lung Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.1944
p.G699W	ACH-000921	Lung Cancer	CCLE	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIMBP2

UniProt ID: O15034

Entrez ID: 23504

Protein name: RIMS-binding protein 2 (RIM-BP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIMBP2 in