DegronMD - O15034(RIMBP2)

FUNCTION: Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. {ECO:0000250}.

GO - Biological processes (BP): neuromuscular synaptic transmission [GO:0007274]

GO - Molecular function (MF):

GO - Cellular component (CC): plasma membrane [GO:0005886]; synapse [GO:0045202]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
PQGTPVST	DEG_SCF_FBW7_1	FBXW7	RIMS-binding protein 2	659:666	More..
PVSTT	DEG_SPOP_SBC_1	SPOP	RIMS-binding protein 2	663:667	More..
KRSVFLE	LIG_APCC_ABBAyCdc20_2	APC,CDC20,FZR1	RIMS-binding protein 2	688:694	More..

Showing 1 to 3 of 3 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P659Q	TCGA-FS-A1ZJ	SKCM	TCGA	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation altering degron motif	0.7035
p.P659Q	DO37956	SKCM	ICGC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation altering degron motif	0.7035
p.S690G	TCGA-BS-A0TJ	UCEC	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.6993
p.S690G	DO42953	UCEC	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.6993
p.R689K	DO48389	BLCA	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.6126
p.V691I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5965
p.V691I	SIDM01147	Gastric Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5965
p.V691L	SIDM00231	Kidney Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5654
p.V691L	NCC010	kidney	COSMIC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5654
p.E694D	TCGA-DA-A3F5	SKCM	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5647
p.E694D	DO37435	SKCM	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5647
p.E687D	TCGA-G4-6323	COAD	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.3056
p.E687D	DO9138	COAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.3056
p.Q658K	DO228974	LICA	ICGC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.3056
p.L656M	TCGA-UZ-A9PS	KIRP	TCGA	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.25
p.L656M	DO219709	KIRP	ICGC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.25
p.L656Q	SIDM00537	Colorectal Carcinoma	GDSC	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.25
p.L656Q	ACH-000982	Colon/Colorectal Cancer	CCLE	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.25
p.L656Q	ACH-001345	Colon/Colorectal Cancer	CCLE	PQGTPVST	DEG_SCF_FBW7_1	659:666	Mutation rewiring degron network	0.25
p.A698V	TCGA-59-2349	OV	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 55 entries

Previous1 2 3Next

Kaplan plot for RIMBP2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIMBP2

UniProt ID: O15034

Entrez ID: 23504

Protein name: RIMS-binding protein 2 (RIM-BP2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RIMBP2 in