DegronMD

Uniprot ID: O15034

Source protein: RIMS-binding protein 2

Source gene: RIMBP2

Class: DEG_SCF_FBW7_1

Location: 659:666

E3 ligase: FBXW7

DEGRON score: 0.8582

ASA_SCORE: 87.7125

COIL: 0.9299

CONS_SCORE: 0.446

DSS_SCORE: 0.6648

HELIX: 0.043

FCONS_SCORE: 1.028

RIG_SCORE: 0.6192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R674W	TCGA-EY-A1GU	UCEC	TCGA	PQGTPVST	DEG_SCF_FBW7_1	0.1111
p.R674W	DO41518	UCEC	ICGC	PQGTPVST	DEG_SCF_FBW7_1	0.1111
p.P659Q	TCGA-FS-A1ZJ	SKCM	TCGA	PQGTPVST	DEG_SCF_FBW7_1	0.7035
p.P659Q	DO37956	SKCM	ICGC	PQGTPVST	DEG_SCF_FBW7_1	0.7035
p.L656M	TCGA-UZ-A9PS	KIRP	TCGA	PQGTPVST	DEG_SCF_FBW7_1	0.25
p.L656M	DO219709	KIRP	ICGC	PQGTPVST	DEG_SCF_FBW7_1	0.25
p.Q658K	DO228974	LICA	ICGC	PQGTPVST	DEG_SCF_FBW7_1	0.3056
p.S649L	DO224745	PACA	ICGC	PQGTPVST	DEG_SCF_FBW7_1	0.0556
p.E675V	DO229259	THCA	ICGC	PQGTPVST	DEG_SCF_FBW7_1	0.0833
p.L656Q	SIDM00537	Colorectal Carcinoma	GDSC	PQGTPVST	DEG_SCF_FBW7_1	0.25
p.L656Q	ACH-000982	Colon/Colorectal Cancer	CCLE	PQGTPVST	DEG_SCF_FBW7_1	0.25
p.L656Q	ACH-001345	Colon/Colorectal Cancer	CCLE	PQGTPVST	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15034	RIMS-binding protein 2	DEG_SCF_FBW7_1	659:666	PQGTPVST	FBXW7	0.8582	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons